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Table 1 Circuits from CoV-Hipathia differentially activated in lung cell lines infected with SARS-CoV-2

From: Mechanistic modeling of the SARS-CoV-2 disease map

KEGG pathway: effector gene/s UP/ DOWN statistic p-valuea FDRb FCc log FC
MAPK signaling pathway: NLK UP 2.882 2.16E-03 0.023 1.098 0.135
MAPK signaling pathway: STK3 UP 2.882 2.16E-03 0.023 1.209 0.274
MAPK signaling pathway: ECSIT, TRAF6 UP 2.882 2.16E-03 0.023 1.182 0.241
Ras signaling pathway: REL UP 2.882 2.16E-03 0.023 1.074 0.103
Ras signaling pathway: MLLT4 UP 2.882 2.16E-03 0.023 1.049 0.069
NF-kappa B signaling pathway: CFLAR UP 2.882 2.16E-03 0.023 1.212 0.278
NF-kappa B signaling pathway: BIRC2 UP 2.882 2.16E-03 0.023 1.261 0.335
NF-kappa B signaling pathway: XIAP UP 2.882 2.16E-03 0.023 1.176 0.234
NF-kappa B signaling pathway: BCL2L1 UP 2.882 2.16E-03 0.023 1.193 0.254
NF-kappa B signaling pathway: GADD45B UP 2.882 2.16E-03 0.023 1.179 0.238
NF-kappa B signaling pathway: BCL2A1 UP 2.882 2.16E-03 0.023 1.570 0.651
NF-kappa B signaling pathway: NFKB2 UP 2.882 2.16E-03 0.023 1.225 0.293
NF-kappa B signaling pathway: CXCL8 UP 2.882 2.16E-03 0.023 1.185 0.245
NF-kappa B signaling pathway: IL1B UP 2.882 2.16E-03 0.023 1.341 0.424
NF-kappa B signaling pathway: TNFAIP3 UP 2.882 2.16E-03 0.023 1.311 0.390
NF-kappa B signaling pathway: NFKBIA UP 2.882 2.16E-03 0.023 1.254 0.327
NF-kappa B signaling pathway: PTGS2 UP 2.882 2.16E-03 0.023 1.267 0.341
NF-kappa B signaling pathway: CXCL2 UP 2.882 2.16E-03 0.023 1.335 0.417
NF-kappa B signaling pathway: IKBKG, CHUK, IKBKB UP 2.882 2.16E-03 0.023 1.110 0.151
NF-kappa B signaling pathway: BCL2L1 UP 2.882 2.16E-03 0.023 1.098 0.135
NF-kappa B signaling pathway: BCL2A1 UP 2.882 2.16E-03 0.023 1.448 0.534
HIF-1 signaling pathway: TIMP1 UP 2.882 2.16E-03 0.023 1.051 0.072
HIF-1 signaling pathway: TIMP1 UP 2.882 2.16E-03 0.023 1.051 0.072
HIF-1 signaling pathway: EDN1 UP 2.882 2.16E-03 0.023 1.121 0.164
HIF-1 signaling pathway: NOS2 UP 2.882 2.16E-03 0.023 1.585 0.664
HIF-1 signaling pathway: PDK1 UP 2.882 2.16E-03 0.023 1.037 0.052
HIF-1 signaling pathway: PGK1 UP 2.882 2.16E-03 0.023 1.048 0.068
HIF-1 signaling pathway: LDHA UP 2.882 2.16E-03 0.023 1.047 0.066
mTOR signaling pathway: VEGFA UP 2.882 2.16E-03 0.023 1.059 0.083
mTOR signaling pathway: TSC1 DOWN −2.882 2.16E-03 0.023 0.946 −0.080
PI3K-Akt signaling pathway: BCL2L11 DOWN −2.882 2.16E-03 0.023 0.918 −0.123
Apoptosis: FADD, TRADD UP 2.882 2.16E-03 0.023 1.118 0.161
Apoptosis: IRAK3, MYD88 UP 2.882 2.16E-03 0.023 1.167 0.223
Toll-like receptor signaling pathway: CXCL10 UP 2.882 2.16E-03 0.023 1.518 0.602
Toll-like receptor signaling pathway: IFNA1 UP 2.882 2.16E-03 0.023 1.486 0.572
Toll-like receptor signaling pathway: IL1B UP 2.882 2.16E-03 0.023 1.172 0.229
Toll-like receptor signaling pathway: IL6 UP 2.882 2.16E-03 0.023 1.526 0.610
RIG-I-like receptor signaling pathway: MAPK14 UP 2.882 2.16E-03 0.023 1.214 0.280
RIG-I-like receptor signaling pathway: MAVS, TMEM173 UP 2.882 2.16E-03 0.023 1.204 0.268
RIG-I-like receptor signaling pathway: IRF7 UP 2.882 2.16E-03 0.023 1.540 0.623
Ras signaling pathway: MAPK8 UP 2.722 4.33E-03 0.035 1.043 0.061
NF-kappa B signaling pathway: TRAF1 UP 2.722 4.33E-03 0.035 1.193 0.254
NF-kappa B signaling pathway: TNF UP 2.722 4.33E-03 0.035 1.639 0.713
HIF-1 signaling pathway: TFRC UP 2.722 4.33E-03 0.035 1.049 0.068
Sphingolipid signaling pathway: SMPD2 UP 2.722 4.33E-03 0.035 1.388 0.473
Apoptosis: FADD, TRADD UP 2.722 4.33E-03 0.035 1.358 0.442
Apoptosis: TRAF2, RIPK1, TRADD UP 2.722 4.33E-03 0.035 1.358 0.442
Toll-like receptor signaling pathway: TNF UP 2.722 4.33E-03 0.035 1.434 0.520
TNF signaling pathway: CASP7 UP 2.722 4.33E-03 0.035 1.388 0.473
TNF signaling pathway: CASP3 UP 2.722 4.33E-03 0.035 1.371 0.455
TNF signaling pathway: BAG4 UP 2.722 4.33E-03 0.035 1.391 0.476
  1. a P-value is calculated using Wilcoxon test
  2. b FDR refers to p-value adjusted for multiple comparisons using Benjamini and Hochberg method
  3. c FC means Fold Change
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