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Table 1 Circuits from CoV-Hipathia differentially activated in lung cell lines infected with SARS-CoV-2

From: Mechanistic modeling of the SARS-CoV-2 disease map

KEGG pathway: effector gene/s

UP/ DOWN

statistic

p-valuea

FDRb

FCc

log FC

MAPK signaling pathway: NLK

UP

2.882

2.16E-03

0.023

1.098

0.135

MAPK signaling pathway: STK3

UP

2.882

2.16E-03

0.023

1.209

0.274

MAPK signaling pathway: ECSIT, TRAF6

UP

2.882

2.16E-03

0.023

1.182

0.241

Ras signaling pathway: REL

UP

2.882

2.16E-03

0.023

1.074

0.103

Ras signaling pathway: MLLT4

UP

2.882

2.16E-03

0.023

1.049

0.069

NF-kappa B signaling pathway: CFLAR

UP

2.882

2.16E-03

0.023

1.212

0.278

NF-kappa B signaling pathway: BIRC2

UP

2.882

2.16E-03

0.023

1.261

0.335

NF-kappa B signaling pathway: XIAP

UP

2.882

2.16E-03

0.023

1.176

0.234

NF-kappa B signaling pathway: BCL2L1

UP

2.882

2.16E-03

0.023

1.193

0.254

NF-kappa B signaling pathway: GADD45B

UP

2.882

2.16E-03

0.023

1.179

0.238

NF-kappa B signaling pathway: BCL2A1

UP

2.882

2.16E-03

0.023

1.570

0.651

NF-kappa B signaling pathway: NFKB2

UP

2.882

2.16E-03

0.023

1.225

0.293

NF-kappa B signaling pathway: CXCL8

UP

2.882

2.16E-03

0.023

1.185

0.245

NF-kappa B signaling pathway: IL1B

UP

2.882

2.16E-03

0.023

1.341

0.424

NF-kappa B signaling pathway: TNFAIP3

UP

2.882

2.16E-03

0.023

1.311

0.390

NF-kappa B signaling pathway: NFKBIA

UP

2.882

2.16E-03

0.023

1.254

0.327

NF-kappa B signaling pathway: PTGS2

UP

2.882

2.16E-03

0.023

1.267

0.341

NF-kappa B signaling pathway: CXCL2

UP

2.882

2.16E-03

0.023

1.335

0.417

NF-kappa B signaling pathway: IKBKG, CHUK, IKBKB

UP

2.882

2.16E-03

0.023

1.110

0.151

NF-kappa B signaling pathway: BCL2L1

UP

2.882

2.16E-03

0.023

1.098

0.135

NF-kappa B signaling pathway: BCL2A1

UP

2.882

2.16E-03

0.023

1.448

0.534

HIF-1 signaling pathway: TIMP1

UP

2.882

2.16E-03

0.023

1.051

0.072

HIF-1 signaling pathway: TIMP1

UP

2.882

2.16E-03

0.023

1.051

0.072

HIF-1 signaling pathway: EDN1

UP

2.882

2.16E-03

0.023

1.121

0.164

HIF-1 signaling pathway: NOS2

UP

2.882

2.16E-03

0.023

1.585

0.664

HIF-1 signaling pathway: PDK1

UP

2.882

2.16E-03

0.023

1.037

0.052

HIF-1 signaling pathway: PGK1

UP

2.882

2.16E-03

0.023

1.048

0.068

HIF-1 signaling pathway: LDHA

UP

2.882

2.16E-03

0.023

1.047

0.066

mTOR signaling pathway: VEGFA

UP

2.882

2.16E-03

0.023

1.059

0.083

mTOR signaling pathway: TSC1

DOWN

−2.882

2.16E-03

0.023

0.946

−0.080

PI3K-Akt signaling pathway: BCL2L11

DOWN

−2.882

2.16E-03

0.023

0.918

−0.123

Apoptosis: FADD, TRADD

UP

2.882

2.16E-03

0.023

1.118

0.161

Apoptosis: IRAK3, MYD88

UP

2.882

2.16E-03

0.023

1.167

0.223

Toll-like receptor signaling pathway: CXCL10

UP

2.882

2.16E-03

0.023

1.518

0.602

Toll-like receptor signaling pathway: IFNA1

UP

2.882

2.16E-03

0.023

1.486

0.572

Toll-like receptor signaling pathway: IL1B

UP

2.882

2.16E-03

0.023

1.172

0.229

Toll-like receptor signaling pathway: IL6

UP

2.882

2.16E-03

0.023

1.526

0.610

RIG-I-like receptor signaling pathway: MAPK14

UP

2.882

2.16E-03

0.023

1.214

0.280

RIG-I-like receptor signaling pathway: MAVS, TMEM173

UP

2.882

2.16E-03

0.023

1.204

0.268

RIG-I-like receptor signaling pathway: IRF7

UP

2.882

2.16E-03

0.023

1.540

0.623

Ras signaling pathway: MAPK8

UP

2.722

4.33E-03

0.035

1.043

0.061

NF-kappa B signaling pathway: TRAF1

UP

2.722

4.33E-03

0.035

1.193

0.254

NF-kappa B signaling pathway: TNF

UP

2.722

4.33E-03

0.035

1.639

0.713

HIF-1 signaling pathway: TFRC

UP

2.722

4.33E-03

0.035

1.049

0.068

Sphingolipid signaling pathway: SMPD2

UP

2.722

4.33E-03

0.035

1.388

0.473

Apoptosis: FADD, TRADD

UP

2.722

4.33E-03

0.035

1.358

0.442

Apoptosis: TRAF2, RIPK1, TRADD

UP

2.722

4.33E-03

0.035

1.358

0.442

Toll-like receptor signaling pathway: TNF

UP

2.722

4.33E-03

0.035

1.434

0.520

TNF signaling pathway: CASP7

UP

2.722

4.33E-03

0.035

1.388

0.473

TNF signaling pathway: CASP3

UP

2.722

4.33E-03

0.035

1.371

0.455

TNF signaling pathway: BAG4

UP

2.722

4.33E-03

0.035

1.391

0.476

  1. a P-value is calculated using Wilcoxon test
  2. b FDR refers to p-value adjusted for multiple comparisons using Benjamini and Hochberg method
  3. c FC means Fold Change