Fig. 1

a Activation pattern of NF-KB pathway in lung cell lines infected with SARS-CoV-2. b Detail of NF-KB pathway’s circuit with TNF as effector protein. c Heatmap representing activation values of all the circuits in COVID-19 disease map (left) and a representation of a Principal Component Analysis based on signaling profiles of the samples that clearly segregates the two conditions studied: controls are represented in dark blue and cases in purple (right). d An example of the Perturbation effect option simulating the effect of Siltuximab (targeting IL6 protein) in Toll-like signaling pathway. Individual gene expression levels in each node are represented green scale. e An example of the Variant interpreter option simulating the effect of a loss of function mutation in NFKBIA protein over lung tissue pathway activity in the TNF signaling pathway. Mean values of gene expression levels in each node are represented in green scale