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Table 2 NPV, PPV, SEN, SPE and AUC values for each of US characteristic in disease nodules

From: Diagnosis of thyroid nodules for ultrasonographic characteristics indicative of malignancy using random forest

Characteristic Benign Malignant NPV PPV SEN SPE AUC
Shape        
AP/T≥1 34(4.7%) 684(95.3%) 29.3% 95.3% 57.0% 86.3% 0.716
AP/T<1 214(29.3%) 516(70.7%) Reference     
Margin        
Regular 174(49.2%) 180(50.8%) Reference     
Irregular 74(6.8%) 1020(93.2%) 49.2% 93.2% 85.0% 70.2% 0.776
Border        
Unclear 55(6.3%) 819(93.7%) 33.6% 93.7% 68.2% 77.8% 0.730
Clear 193(33.6%) 381(66.4%) Reference     
Hackly border        
Present 22(3.0%) 744(97%) 33.1% 97.1% 62.0% 91.1% 0.766
Absent 226 (33.1%) 456(66.9%) Reference     
Component        
Solid 108(8.5%) 1157(91.5%) 76.5% 91.5% 96.4% 56.5% 0.764
Mixed 140(76.5%) 43(23.5%) Reference     
Calcifications        
Macro-calcifications 30(18.0%) 137(82.0%) 17.0% 82.0% 11.4% 87.9% 0.497
Micro-calcifications 78(9.9%) 711(90.1%) 25.8% 90.1% 59.2% 68.5% 0.639
No calcifications 140(28.5%) 352(71.5%) Reference     
Halo        
Present 209(15.7%) 1123(84.3%) 33.6% 84.3% 93.6% 15.7% 0.547
Absent 39(33.6%) 77(66.4%) Reference     
Attenuation        
Present 12(5.5%) 208(94.5%) 19.2% 94.5% 17.3% 95.2% 0.562
Absent 236(19.2%) 992(80.8%) Reference     
Lateral shadow        
Present 5(8.8%) 52(91.2%) 17.5% 91.2% 4.3% 98.0% 0.512
Absent 243(17.5%) 1148(82.5%) Reference     
Blood flow degree        
Low 49(10.5%) 417(89.5%) 20.3% 89.5% 34.8% 80.2% 0.575
Medium 116(22.7%) 396(77.3%) Reference     
High 83(17.7%) 387(82.3%) 16.9% 82.3% 32.2% 66.5% 0.494
Vascularity        
Peripheral 78(23.8%) 250(76.2%) Reference     
Mixed 69(23.2%) 228(76.8%) 15.6% 76.8% 19.0% 72.2% 0.456
Central 101(12.3%) 722(87.7%) 23.5% 87.7% 60.2% 59.3% 0.597
Echogenicity        
Hypoechoic 117(11.3%) 920(88.7%) 31.9% 88.7% 76.7% 52.8% 0.647
Hyperechoic 131(31.9%) 280(68.1%) Reference     
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