Application of network pharmacology and molecular docking to elucidate the potential mechanism of Eucommia ulmoides-Radix Achyranthis Bidentatae against osteoarthritis

Table 3 Virtual docking of four bioactive ingredients from Eucommia ulmoides (EU)-Radix Achyranthis Bidentatae (RAB) for Osteoarthritis (OA) targets

No	Compound	Structure	Binding Energy /(kcal·mol⁻¹)
No	Compound	Structure	EGFR	ESR1	MAPK8	GSK3β	IKBKB
1	quercetin		−6.9327	−6.8972	− 7.1388	− 6.1622	−7.1583
2	kaempferol		−7.0913	− 6.3109	−6.6991	− 6.1155	−6.5508
3	wogonin		−6.4374	− 6.4663	−6.7080	− 6.1687	−6.9841
4	baicalein		−6.3727	− 6.5548	−6.9782	−5.2388	− 6.3864

ISSN: 1756-0381