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Table 3 Age Adjusted Higher-Order Interaction Models Associated with BDR identified by ViSEN

From: An epistatic interaction between pre-natal smoke exposure and socioeconomic status has a significant impact on bronchodilator drug response in African American youth with asthma

A. Full Dataset
  ViSEN Analysis Logistic
Regression
Age Adjusted
Variable 1 Variable 2 Variable 3 IG p-value OR p-value
Experience of Discrimination Age Socioeconomic Status 2.39% 0.003 0.029 0.008
Experience of Discrimination African Ancestry Socioeconomic Status 1.71% 0.012 0.026 0.040
Experience of Discrimination NO2 Air
Pollution
Socioeconomic Status 1.80% 0.017 0.043 0.013
Sex Pre-natal Smoke
Exposure
Socioeconomic Status 1.82% 0.041 1.525 0.817
Experience of Discrimination Pre-natal Smoke Exposure NO2 Air
Pollution
1.66% 0.043
B. Sex-Stratified Subsets
  ViSEN Analysis Logistic
Regression
Age Adjusted
Subset Variable 1 Variable 2 Variable 3 IG p-value OR p-value
Female Experience of Discrimination Pre-natal Smoke Exposure African Ancestry 2.73% 0.018 1.000 1.000
Pre-natal Smoke Exposure Socioeconomic Status NO2 Air Pollution 4.92% 0.030 0.091 0.413
Experience of Discrimination Pre-natal Smoke Exposure Age 4.01% 0.039
Male Experience of Discrimination African Ancestry Socioeconomic Status 5.11% 0.001a 0.004 0.005
Experience of Discrimination NO2 Air Pollution Socioeconomic Status 3.95% 0.008 0.012 0.015
Experience of Discrimination Age Socioeconomic Status 3.90% 0.012 0.012 0.017
Experience of Discrimination African Ancestry NO2 Air Pollution 2.44% 0.038
  1. Information Gain (IG) and unadjusted permutation p-value results for select interaction models associated (permutation unadj. p < 0.05) with BDR identified by the age adjusted ViSEN and logistic regression analyses. Positive IG values indicate synergistic interactions, negative IG values indicate redundant models. The Bonferroni method was used to correct for multiple testing. Bonferroni familywise error rate (FWER) thresholds of 0.05 and 0.1 were used to determine significantly associated models (permutation unadj. p ≤ 0.0009) and suggestively associated (permutation unadj. p ≤ 0.002), respectively. Models significantly associated with BDR after correction for multiple testing are highlighted in BOLD. Models suggestively associated with BDR after correction for multiple testing are indicated with a. Logistic regression analysis was performed in the same LCC age adjusted dataset as VISEN analyses for accurate comparison of results; to maintain consistency with ViSEN analyses regression models were adjusted for the marginal effects of each independent variable included in the specified interaction model. When interaction bin size was < 5, Firth’s Bias-Reduced logistic regression OR and p-values are presented. ---: model could not be accurately assessed by regression modeling due to deviation from model assumptions of no collinearity and no complete or quasi-complete separation; OR: Odd’s Ratio
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