Skip to main content

Table 2 Age Adjusted Pairwise Interaction Models Associated with BDR Identified by ViSEN

From: An epistatic interaction between pre-natal smoke exposure and socioeconomic status has a significant impact on bronchodilator drug response in African American youth with asthma

A. Full Dataset
  ViSEN Analysis Logistic Regression
Variable 1 Variable 2 IG p-value OR p-value
Pre-natal Smoke Exposure Socioeconomic Status 2.78% 0.001 0.105 0.004a
Experience of Discrimination Socioeconomic Status 2.71% 0.002a 0.166 0.003a
Sex Socioeconomic Status 1.47% 0.026 0.291 0.031
B. Sex-Stratified Subsets
  ViSEN Analysis Logistic Regression
Subset Variable 1 Variable 2 IG p-value OR p-value
Female
N = 97
Pre-natal Smoke
Exposure
Socioeconomic
Status
7.27% 0.004a 0.054 0.033
Experience of
Discrimination
Socioeconomic
Status
4.52% 0.016 0.093 0.014
Male
N = 136
Experience of
Discrimination
Socioeconomic
Status
3.04% 0.015 0.135 0.035
Pre-natal Smoke
Exposure
Socioeconomic
Status
2.69% 0.032 0.082 0.038
  1. Information Gain (IG) and unadjusted permutation p-value results for select interaction models (permutation unadj. p < 0.05) with BDR identified by the age adjusted ViSEN and logistic regression analyses. Positive IG values indicate synergistic interactions, negative IG values indicate redundant models. The Bonferroni method was used to correct for multiple testing. Bonferroni familywise error rate (FWER) thresholds of 0.05 and 0.1 were used to determine significantly associated models (permutation unadj. p ≤ 0.002) and suggestively associated (permutation unadj. p ≤ 0.004), respectively. Models significantly associated with BDR after correction for multiple testing are highlighted in BOLD. Models suggestively associated with BDR after correction for multiple testing are indicated with a. Logistic regression models were adjusted for age and the marginal effects of each independent variable included in the specified interaction model. SES: Socioeconomic Status; Smoking: Pre-natal smoke exposure; EOD: Experience of Discrimination; OR: Odd’s Ratio
\