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Table 2 Age Adjusted Pairwise Interaction Models Associated with BDR Identified by ViSEN

From: An epistatic interaction between pre-natal smoke exposure and socioeconomic status has a significant impact on bronchodilator drug response in African American youth with asthma

A. Full Dataset

Ā 

ViSEN Analysis

Logistic Regression

Variable 1

Variable 2

IG

p-value

OR

p-value

Pre-natal Smoke Exposure

Socioeconomic Status

2.78%

0.001

0.105

0.004a

Experience of Discrimination

Socioeconomic Status

2.71%

0.002a

0.166

0.003a

Sex

Socioeconomic Status

1.47%

0.026

0.291

0.031

B. Sex-Stratified Subsets

Ā 

ViSEN Analysis

Logistic Regression

Subset

Variable 1

Variable 2

IG

p-value

OR

p-value

Female

Nā€‰=ā€‰97

Pre-natal Smoke

Exposure

Socioeconomic

Status

7.27%

0.004a

0.054

0.033

Experience of

Discrimination

Socioeconomic

Status

4.52%

0.016

0.093

0.014

Male

Nā€‰=ā€‰136

Experience of

Discrimination

Socioeconomic

Status

3.04%

0.015

0.135

0.035

Pre-natal Smoke

Exposure

Socioeconomic

Status

2.69%

0.032

0.082

0.038

  1. Information Gain (IG) and unadjusted permutation p-value results for select interaction models (permutation unadj. pā€‰<ā€‰0.05) with BDR identified by the age adjusted ViSEN and logistic regression analyses. Positive IG values indicate synergistic interactions, negative IG values indicate redundant models. The Bonferroni method was used to correct for multiple testing. Bonferroni familywise error rate (FWER) thresholds of 0.05 and 0.1 were used to determine significantly associated models (permutation unadj. pā€‰ā‰¤ā€‰0.002) and suggestively associated (permutation unadj. pā€‰ā‰¤ā€‰0.004), respectively. Models significantly associated with BDR after correction for multiple testing are highlighted in BOLD. Models suggestively associated with BDR after correction for multiple testing are indicated with a. Logistic regression models were adjusted for age and the marginal effects of each independent variable included in the specified interaction model. SES: Socioeconomic Status; Smoking: Pre-natal smoke exposure; EOD: Experience of Discrimination; OR: Oddā€™s Ratio