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Table 2 In silico validation of gene candidates for four disease phenotypes

From: Identification of therapeutic targets from genetic association studies using hierarchical component analysis

 

AMD

CD

UC

RA

GWAS components + BNs (p1)

 LINCS hits

0.059 (3/51)

0.143 (2/14)

0.146 (6/41)

0.326 (17/52)

 MGI hits

0.311 (42/135)

0.326 (15/46)

0.361 (35/97)

0.493 (73/148)

S-Predixcan (p2)

 LINCS hits

0.093 (5/54)

0.243 (18/74)

0.121 (7/58)

0.237 (22/93)

 MGI hits

0.227 (29/128)

0.367 (50/136)

0.269 (28/104)

0.277 (57/206)

p1– p2

 LINCS hits

−0.034

−0.1

0.025

0.089

 MGI hits

0.084

− 0.047

0.092

0.216***

  1. Numerators represent hits, and denominators represent the number of genes retrieved by GWAS components + BNs or S-PrediXcan. *** indicates p < 0.001