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Table 2 In silico validation of gene candidates for four disease phenotypes

From: Identification of therapeutic targets from genetic association studies using hierarchical component analysis

  AMD CD UC RA
GWAS components + BNs (p1)
 LINCS hits 0.059 (3/51) 0.143 (2/14) 0.146 (6/41) 0.326 (17/52)
 MGI hits 0.311 (42/135) 0.326 (15/46) 0.361 (35/97) 0.493 (73/148)
S-Predixcan (p2)
 LINCS hits 0.093 (5/54) 0.243 (18/74) 0.121 (7/58) 0.237 (22/93)
 MGI hits 0.227 (29/128) 0.367 (50/136) 0.269 (28/104) 0.277 (57/206)
p1– p2
 LINCS hits −0.034 −0.1 0.025 0.089
 MGI hits 0.084 − 0.047 0.092 0.216***
  1. Numerators represent hits, and denominators represent the number of genes retrieved by GWAS components + BNs or S-PrediXcan. *** indicates p < 0.001