Fig. 1

Schematic diagram of GWAS component analysis. a We designed a two-stage method to map SNP associations to component associations. Associated GWAS components were integrated with Bayesian networks to facilitate therapeutic discovery. GWAS component is a component with a score \( {Z}_l^L \) significantly deviating from 0. b In the first stage, S-PrediXcan was used to infer gene associations from SNP associations. Gene-to-Component model were fitted by WGCNA, and the corresponding associations were computed as in Eq. (2) (see text). Models in B) were built using GTEx reference data