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Table 1 The major targets of QYG for AD treatment and its relevant topological parameters

From: A network pharmacology-based study on Alzheimer disease prevention and treatment of Qiong Yu Gao

Uniprot IDProtein nameGene nameDegreeBetweenness centralityCloseness centralityAverage shortest path length
P18031Tyrosine-protein phosphatase non-receptor type 1PTPN1260.0661060.3379312.959184
P05230Fibroblast growth factor 1FGF1250.0416480.3426572.918367
P09038Fibroblast growth factor 2FGF2240.0331460.3344712.989796
P10636Microtubule-associated protein tauMAPT180.0385010.3096373.229592
P08172Muscarinic acetylcholine receptor M2CHRM2160.025880.3197393.127551
P00918Carbonic anhydrase 2CA2150.0691460.3456792.892857
P11229Muscarinic acetylcholine receptor M1CHRM1150.0265180.3245033.081633
P40763Signal transducer and activator of transcription 3STAT3150.0113360.3151133.173469
P10275Androgen receptorAR140.0373050.3609582.770408
P11511Cytochrome P450 19A1CYP19A1140.0244610.3327673.005102
P28845Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1140.0296860.3456792.892857
Q13133Oxysterols receptor LXR-alphaNR1H3140.0084210.3111113.214286
P040353-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR130.0304420.340872.933673
P60568Interleukin-2IL2130.0110530.3161293.163265
Q92731Estrogen receptor betaESR2120.0163220.3294123.035714
P04150Glucocorticoid receptorNR3C1110.0190690.3316413.015306
P11473Vitamin D receptorVDR110.0073780.3111113.214286