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Table 3 Multivariate analysis of the Cox proportional hazard regression model of resected T1-3N0 − 2 M0 NSCLC

From: RNSCLC-PRSP software to predict the prognostic risk and survival in patients with resected T1-3N0–2 M0 non-small cell lung cancer

Factors

Variates

b

SE

RR

95%CI

P

Gender

X1

0.379

0.053

1.460

1.317~1.620

< 0.001

Age

X2

−0.403

0.054

0.668

0.601~0.743

< 0.001

N stage

0.001

 N0

X50

−0.372

0.195

0.689

0.470~1.010

0.056

 N1

X51

−0.267

0.075

0.766

0.661~0.886

< 0.001

NELNs

< 0.001

 6<N ≤ 12

X61

−0.167

0.060

0.846

0.751~0.952

0.006

 N>12

X62

−0.298

0.064

0.742

0.655~0.841

< 0.001

NPLNs

0.003

 1 ≤ N ≤ 3

X71

0.460

0.197

1.583

1.077~2.328

0.019

 N ≥ 4

X72

0.617

0.203

1.854

1.245~2.762

0.002

Surgery type

0.001

 LET

X81

−0.344

0.090

0.709

0.595~0.845

< 0.001

 PET

X82

−0.245

0.127

0.783

0.611~1.003

0.053

Primary site

0.035

 Others

X90

−0.308

0.172

0.735

0.525~1.029

0.073

 UL

X91

−0.105

0.053

0.900

0.811~0.999

0.047

 ML

X92

−0.243

0.116

0.784

0.625~0.983

0.035

Histological grade

< 0.001

 II

X101

0.305

0.100

1.356

1.114~1.651

0.002

 III

X102

0.508

0.101

1.663

1.364~2.027

< 0.001

 IV

X103

0.754

0.167

2.126

1.532~2.950

< 0.001

Histology

0.011

 AC

X111

0.143

0.066

1.153

1.013~1.313

0.031

 S

X112

0.170

0.073

1.186

1.028~1.368

0.019

 ASC

X113

0.434

0.137

1.544

1.181~2.019

0.001

 BAA

X114

−0.030

0.160

0.970

0.709~1.328

0.851

Marital status

< 0.001

 Others

X120

0.016

0.221

1.016

0.659~1.566

0.944

 Single (never married)

X121

−0.133

0.098

0.875

0.723~1.060

0.172

 Married

X122

−0.327

0.071

0.721

0.628~0.829

< 0.001

 Divorced

X123

−0.247

0.094

0.781

0.650~0.938

0.008

Tumor extensiona

< 0.001

 T2 Visc PI

X131

−0.115

0.087

0.892

0.752~1.056

0.185

 T2 Centr

X132

0.025

0.092

1.025

0.856~1.229

0.786

 T3 Inv

X133

0.517

0.204

1.678

1.125~2.500

0.011

 T3 Satell

X134

0.340

0.095

1.405

1.167~1.692

< 0.001

Tumor sizea

< 0.001

 T1b>1–2(1<T ≤ 2)

X141

0.025

0.174

1.025

0.729~1.442

0.886

 T1c>2–3(2<T ≤ 3)

X142

0.260

0.171

1.297

1.927~1.815

0.129

 T2a>3–4(3<T ≤ 4)

X143

0.457

0.174

1.580

1.122~2.223

0.009

 T2b>4–5(4<T ≤ 5)

X144

0.419

0.179

1.520

1.069~2.161

0.020

 T3>5–7(5<T ≤ 7)

X145

0.407

0.180

1.502

1.055~2.140

0.024

  1. Abbreviations: b Regression coefficient, SE Standard error, RR Relative risk, CI Confidence interval, NELNs Number of examined regional lymph nodes, NPLNs Number of positive regional lymph nodes, LET Lobectomy, PET Pneumonectomy, UL Upper lobe, ML Middle lobe, II Moderately differentiated, III Poorly differentiated, IV Undifferentiated, AC Adenocarcinoma, S Squamous carcinoma, ASC Adenosquamous carcinoma, BAA Bronchioalveolar adenocarcinoma
  2. a According to the eighth edition AJCC/UICC stage classification for NSCLC
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