Fig. 5

Sensitivities of MB-MDR to detect two-loci pure epistatic interaction in 4 settings at three effect sizes and with different LD pruning levels: Signal sensitivities (upper panel) and exact sensitivities (lower panel) are displayed at different LD pruning thresholds (unpruned data or LD pruning at 0.75, 0.60, 0.50 and 0.20). Signal sensitivities determined with tag-SNP subsets at LD r2≥0.45 with causal SNPs