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Table 2 Co-conservation class comparison table. P-values for comparisons of the distributions of coevolution scores for each possible pairing of co-conservation classes of eQTL interactions (calculated using the two-sided KS-test)

From: Characterizing human genomic coevolution in locus-gene regulatory interactions

Class 1

Class 2

p-value

High conservation SNP

High conservation SNP

 

High conservation target

Low conservation target

p<1.045×10−6

High conservation SNP

Low conservation SNP

 

High conservation target

High conservation target

p<1.11×10−15

High conservation SNP

Low conservation SNP

 

High conservation target

Low conservation target

p<2.2×10−16

High conservation SNP

Low conservation SNP

 

Low conservation target

High conservation target

p<8.946×10−9

High conservation SNP

Low conservation SNP

 

Low conservation target

Low conservation target

p<2.2×10−16

Low conservation SNP

Low conservation SNP

 

High conservation target

Low conservation target

p<2.2×10−16