Table 3 Top ten mutated genes within pediatric glioma samples from data amongst several web resources (PedcBioPortal, cBioPortal, ICGC Data Portal, Pecan)
From: Use case driven evaluation of open databases for pediatric cancer research
Overall mutation frequency | Gene | Encoded protein | Function |
|---|---|---|---|
25% | BRAF | B-Raf proto-oncogene | RAS/MAPK signaling for proliferation, differentiation, migration and apoptosis |
21% | TP53 | tumor protein 53 | tumor suppressor, “guardian of the genome” |
18% | KIAA1549 | UPF0606 protein KIAA1549 | transcription regulation |
16% | H3F3A | H3 histone family member 3A | DNA accessibility |
13% | ATRX | alpha thalassemia/mental retardation syndrome X-linked protein | chromatin remodeler |
13% | IDH1 | isocitrate dehydrogenase 1 | energy metabolism |
5% | CDR2 | Cerebellar Degeneration Related Protein 2 | Myc-regulation |
4% | PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | phosphorylation, signaling for proliferation and migration |
4% | NF1 | neurofibromin 1 | tumor suppressor |
3% | C17ORF47 | Chromosome 17 Open Reading Frame 47 | uncharacterized protein |