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Table 3 Top ten mutated genes within pediatric glioma samples from data amongst several web resources (PedcBioPortal, cBioPortal, ICGC Data Portal, Pecan)

From: Use case driven evaluation of open databases for pediatric cancer research

Overall mutation frequency Gene Encoded protein Function
25% BRAF B-Raf proto-oncogene RAS/MAPK signaling for proliferation, differentiation, migration and apoptosis
21% TP53 tumor protein 53 tumor suppressor, “guardian of the genome”
18% KIAA1549 UPF0606 protein KIAA1549 transcription regulation
16% H3F3A H3 histone family member 3A DNA accessibility
13% ATRX alpha thalassemia/mental retardation syndrome X-linked protein chromatin remodeler
13% IDH1 isocitrate dehydrogenase 1 energy metabolism
5% CDR2 Cerebellar Degeneration Related Protein 2 Myc-regulation
4% PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha phosphorylation, signaling for proliferation and migration
4% NF1 neurofibromin 1 tumor suppressor
3% C17ORF47 Chromosome 17 Open Reading Frame 47 uncharacterized protein