Unified Cox model based multifactor dimensionality reduction method for gene-gene interaction analysis of the survival phenotype

Table 3 Comparison of the log-rank tests between no SNP effect model and SNP effect model attributed by Cox UM-MDR and Cox-MDR

Model	Covariates	Log-rank test	p-value
No SNP effect model	Age, Sex	12.798	0.0003
SNP effect model by Cox UM-MDR	Age, Sex, (rs747199, rs2847153)^a	18.341	0.0000
SNP effect model by Cox UM-MDR	Age, Sex, (rs1960207, rs1004474)^a	20.672	0.0000
SNP effect model by Cox-MDR	Age, Sex, (rs532545, rs2847153)^a	8.976	0.0027
SNP effect model by Cox-MDR	Age, Sex, (rs12404655, rs1004474)^a	17.278	0.0000

^a denotes the model including two main effects of SNP1 and SNP2 and their interaction effect

ISSN: 1756-0381