Fig. 1From: Application of an interpretable classification model on Early Folding Residues during protein foldingIllustration of the protein folding process. The denatured protein (a) has to pass an energetic barrier (‡), the so-called transition state, to reach its native three-dimensional structure (b). Usually, the native structure represents the global energetic optimum of the protein. EFR are residues which initiate and guide the folding process [13, 19]Back to article page