Prediction tool | Fold Enrichment | FDR B&H |
---|
CADD | 32.2 | 9.54E-03 |
GWAVA | 23.9 | 8.17E-03 |
Eigen-PC | 20.1 | 2.14E-02 |
CADD+GWAVA+Eigen-PC | 77.9 | 8.68E-08 |
- Fold-enrichment was calculated as ((m/n)/(M/N), where m is the number of prioritized genes (with a tool or a combination of tools) belong to KC, n is the total number of genes prioritized using a tool (or a combination of tools), M is the total number of genes associated with KC, and N is the human genome background (around 20,000 genes). Enrichment P-values were calculated using probability density function, and the Benjamini-Hochberg procedure was used for multiple testing corrections