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Table 3 Summary of the enrichment scores for genes prioritized for keratoconus (KC) using a combination of CADD, GWAVA, and Eigen prediction tool

From: Functional relevance for central cornea thickness-associated genetic variants by using integrative analyses

Prediction tool

Fold Enrichment

FDR B&H

CADD

32.2

9.54E-03

GWAVA

23.9

8.17E-03

Eigen-PC

20.1

2.14E-02

CADD+GWAVA+Eigen-PC

77.9

8.68E-08

  1. Fold-enrichment was calculated as ((m/n)/(M/N), where m is the number of prioritized genes (with a tool or a combination of tools) belong to KC, n is the total number of genes prioritized using a tool (or a combination of tools), M is the total number of genes associated with KC, and N is the human genome background (around 20,000 genes). Enrichment P-values were calculated using probability density function, and the Benjamini-Hochberg procedure was used for multiple testing corrections