Table 5 Functions of hub genes ELAVL1, JUN, and MMP2
From: Integrative analysis of gene expression and methylation data for breast cancer cell lines
Gene | Function |
|---|---|
ELAVL1 | Encodes a protein that contains several NA recognition motifs [17]. Selectively binds AU-rich elements in 3′ untranslated regions of mRNAs. Highly expressed in many cancers. |
JUN | Encodes a protein that is highly similar to the avian sarcoma virus 17 protein and interacts directly with target DNA sequences to regulate gene expression [17]. It is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. |
MMP2 | Protein coding gene with various functions that include tumor invasion and metastasis [17]. Also associated with estrogen receptor signaling. |