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Table 5 Functions of hub genes ELAVL1, JUN, and MMP2

From: Integrative analysis of gene expression and methylation data for breast cancer cell lines

Gene Function
ELAVL1 Encodes a protein that contains several NA recognition motifs [17].
Selectively binds AU-rich elements in 3′ untranslated regions of mRNAs.
Highly expressed in many cancers.
JUN Encodes a protein that is highly similar to the avian sarcoma virus 17 protein and interacts directly with target DNA sequences to regulate gene expression [17]. It is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
MMP2 Protein coding gene with various functions that include tumor invasion and metastasis [17]. Also associated with estrogen receptor signaling.