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Fig. 2 | BioData Mining

Fig. 2

From: Connecting genetics and gene expression data for target prioritisation and drug repositioning

Fig. 2

Genes differentially expressed after treatment with drug approved for a disease are enriched for genes genetically associated with the same disease. a Boxplots showing distributions of Fisher’s exact test p-values between GWAS disease associations and DEGs after drug treatment for current and other indications. b ROC curve with 95% confidence interval obtained using current indications as positive labels and significance of enrichment between genetic hits in disease and drug transcriptomic profiles as the ranking metric. c Barplot showing breakdown of current drug indications by therapeutic area where there is a significant overlap between GWAS associations and DEGs after drug treatment

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