|
Disc. Rank
|
SNP 1
|
SNP 2
|
Locus 1
|
Locus 2
|
Beta
|
LRT p
|
Rep. Beta
|
Rep. LRT p
|
Rep. Cohorta
|
---|
HDL
|
1
|
rs12720918
|
rs4783961
|
CETP
|
CETP
|
−0.06
|
9.5 × 10−20
|
−0.07
|
3.0 × 10−12
|
P,W,L
|
2
|
rs12720918
|
rs158477
|
CETP
|
CETP
|
−0.06
|
6.3 × 10−16
|
−0.07
|
2.9 × 10−10
|
P,W,L
|
3
|
rs1864163
|
rs4783961
|
CETP
|
CETP
|
−0.06
|
4.5 × 10−15
|
−0.05
|
7.1 × 10−7
|
P,W,B
|
5
|
rs1864163
|
rs158477
|
CETP
|
CETP
|
−0.06
|
1.3 × 10−12
|
−0.05
|
2.3 × 10−8
|
P
|
6
|
rs12708967
|
rs820299
|
CETP
|
CETP
|
0.06
|
1.0 × 10−11
|
0.06
|
1.6 × 10−6
|
P,W,L
|
7
|
rs1864163
|
rs4784744
|
CETP
|
CETP
|
0.05
|
2.6 × 10−11
|
0.06
|
5.2 × 10−11
|
P,W
|
8
|
rs1800775
|
rs4783961
|
CETP
|
CETP
|
0.04
|
6.3 × 10−11
|
−0.08
|
2.4 × 10−7
|
B
|
9
|
rs12708967
|
rs158477
|
CETP
|
CETP
|
−0.05
|
2.5 × 10−10
|
−0.06
|
1.1 × 10−6
|
P,W,L
|
10
|
rs9939224
|
rs4783961
|
CETP
|
CETP
|
−0.05
|
2.5 × 10−10
|
−0.04
|
2.4 × 10−7
|
W,B
|
12
|
rs1800775
|
rs158477
|
CETP
|
CETP
|
0.04
|
1.8 × 10−8
|
0.07
|
2.5 × 10−6
|
B
|
13
|
rs9939224
|
rs478474
|
CETP
|
CETP
|
0.04
|
5.4 × 10−7
|
0.07
|
2.4 × 10−10
|
P
|
17
|
rs1800775
|
rs4784744
|
CETP
|
CETP
|
−0.03
|
1.8 × 10−6
|
−0.05
|
9.7 × 10−7
|
W
|
18
|
rs9939224
|
rs12447924
|
CETP
|
CETP
|
0.05
|
1.8 × 10−6
|
0.06
|
5.3 × 10−7
|
P
|
38
|
rs7013777
|
rs9644636
|
LPL
|
LPL
|
−0.03
|
8.0 × 10−5
|
−0.04
|
7.5 × 10−6
|
W
|
50
|
rs820299
|
rs8056954
|
CETP
|
SLC12A3
|
0.03
|
1.8 × 10−4
|
0.06
|
1.5 × 10−5
|
W
|
66
|
rs12708967
|
rs4784744
|
CETP
|
CETP
|
0.03
|
3.0 × 10−4
|
0.05
|
2.4 × 10−5
|
P
|
133
|
rs6586891
|
rs285
|
LPL
|
LPL
|
−0.02
|
7.9 × 10−4
|
−0.04
|
2.9 × 10−5
|
P
|
LDL
|
7
|
rs1531517
|
rs519113
|
BCL3
|
PVRL2
|
−0.16
|
7.9 × 10−6
|
−0.2
|
5.2 × 10−6
|
P,B
|
70
|
rs4803766
|
rs157580
|
PVRL2
|
TOMM40
|
−0.06
|
3.4 × 10−4
|
−0.11
|
4.8 × 10−7
|
P,B
|
TC
|
33
|
rs11216129
|
rs10750097
|
BUD13
|
APOA5
|
−0.12
|
1.3 × 10−4
|
−0.22
|
1.4 × 10−5
|
W
|
TG
|
1
|
rs4938303
|
rs180327
|
BUD13
|
BUD13
|
0.09
|
1.2 × 10−21
|
0.08
|
9.5 × 10−7
|
P,W
|
2
|
rs2075295
|
rs6589568
|
BUD13
|
APOA4
|
−0.10
|
4.4 × 10−19
|
−0.15
|
3.5 × 10−15
|
P,W
|
3
|
rs180327
|
rs10750097
|
BUD13
|
APOA5
|
0.08
|
3.1 × 10−14
|
0.31
|
6.8 × 10−9
|
W,B
|
4
|
rs180327
|
rs2075295
|
BUD13
|
BUD13
|
0.07
|
8.9 × 10−13
|
0.07
|
1.5 × 10−5
|
P
|
5
|
rs180327
|
rs6589568
|
BUD13
|
APOA4
|
0.07
|
2.7 × 10−10
|
0.08
|
5.6 × 10−6
|
W
|
6
|
rs11216129
|
rs10750097
|
BUD13
|
APOA5
|
−0.12
|
2.1 × 10−9
|
−0.12
|
2.6 × 10−7
|
W,P
|
13
|
rs180327
|
rs618923
|
BUD13
|
ZPR1
|
−0.08
|
3.7 × 10−7
|
−0.08
|
1.0 × 10−5
|
W
|
15
|
rs2075295
|
rs1263173
|
BUD13
|
APOA4
|
−0.08
|
2.1 × 10−7
|
−0.08
|
3.5 × 10−6
|
W
|
19
|
rs486394
|
rs4938303
|
BUD13
|
BUD13
|
0.07
|
2.1 × 10−6
|
0.07
|
2.9 × 10−5
|
P
|
49
|
rs2075295
|
rs10047459
|
BUD13
|
APOA1
|
−0.11
|
2.1 × 10−5
|
−0.11
|
6.9 × 10−8
|
W
|
153
|
rs2075295
|
rs10750097
|
BUD13
|
APOA5
|
−0.09
|
2.1 × 10−4
|
−0.09
|
2.9 × 10−6
|
W
|
-
LRT likelihood ratio test. aSee Table 1 for details on cohorts