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Table 1 Details for the five cohorts that were merged to create the discovery dataset and the 10 cohorts used for replication

From: Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

  Study (One letter label) Recruitment design Year of collection N totala Data Level Study Ref (PMID)
Discovery (IBC) ARIC Community-based 1985–2006 9588 Individual 20400780
CARDIA Community-based 1985–2003 1443 Individual 20400780
CHS Community-based 1988–2005 3952 Individual 20400780
FHS Community-based 1948-present 7556 Individual 20,400,780
MESA Community-based 1999–2009 2298 Individual 20400780
Replication (IBC) BOSS/EHLS/BDES Population-based cohort 1988-present 1568 Summary 21339392, 9801018, 1923372
BWHHS (B) Population-based cohort 1999–2001 3411 Summary 16045529
CLEAR Case-control 2005 1591 Summary 16474172
EPIC-NL Nested case-control 1993–1997 5194 Summary 19483199
GIRaFH Cohort 1999 1694 Summary 15554949
KORA Population-based cohort 1984–2005 1849 Summary 16032513, 1603251
LURIC (L) Case-control 1997–2002 2813 Summary 11258203
PROCARDIS (P) Case-control 1998-present 6432 Summary 20032323
Whitehall II (W) Population-based cohort 1985–1989 4882 Summary 15576467
Rep. (GWAS) eMERGE Consortium   7504 Summary 23743551
  1. Discovery cohorts: Atherosclerosis Risk In Communities (ARIC); Coronary Artery Risk Development in Young Adults (CARDIA); Cardiovascular Health Study (CHS); Framingham Heart Study (FHS); Multi-Ethnic Study of Atherosclerosis (MESA)
  2. Replication cohorts: BOSS beaver dam offspring study, EHLS epidemiology of hearing loss study, BDES beaver dam eye study, AIBIII Allied Irish Bank Workers Study III, AMC-PAS Academic Medical Center Amsterdam Premature Atherosclerosis Study, ASCOT anglo-scandinavian cardiac outcomes trial, BHS bogalusa heart study, BRIGHT, British genetics of hypertension, BWHHS British women’s heart and health study, CLEAR carotid lesion epidemiology and risk, EPIC-NL European Prospective Investigation into Cancer and Nutrition in the Netherlands, GIRaFH genetic identification of risk factors in familial hypercholesterolemia, KORA Kooperative Gesundheitsforschung in der Region Augsburg, LURIC Ludwigshafen Risk and Cardiovascular Health Study, PROCARDIS precocious coronary artery disease study, WHII Whitehall II study, GWAS eMERGE
  3. aNumbers varied for each lipid trait. The number shown is the maximum number of non-missing individuals for all traits