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Table 1 Details for the five cohorts that were merged to create the discovery dataset and the 10 cohorts used for replication

From: Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

 

Study (One letter label)

Recruitment design

Year of collection

N totala

Data Level

Study Ref (PMID)

Discovery (IBC)

ARIC

Community-based

1985–2006

9588

Individual

20400780

CARDIA

Community-based

1985–2003

1443

Individual

20400780

CHS

Community-based

1988–2005

3952

Individual

20400780

FHS

Community-based

1948-present

7556

Individual

20,400,780

MESA

Community-based

1999–2009

2298

Individual

20400780

Replication (IBC)

BOSS/EHLS/BDES

Population-based cohort

1988-present

1568

Summary

21339392, 9801018, 1923372

BWHHS (B)

Population-based cohort

1999–2001

3411

Summary

16045529

CLEAR

Case-control

2005

1591

Summary

16474172

EPIC-NL

Nested case-control

1993–1997

5194

Summary

19483199

GIRaFH

Cohort

1999

1694

Summary

15554949

KORA

Population-based cohort

1984–2005

1849

Summary

16032513, 1603251

LURIC (L)

Case-control

1997–2002

2813

Summary

11258203

PROCARDIS (P)

Case-control

1998-present

6432

Summary

20032323

Whitehall II (W)

Population-based cohort

1985–1989

4882

Summary

15576467

Rep. (GWAS)

eMERGE

Consortium

 

7504

Summary

23743551

  1. Discovery cohorts: Atherosclerosis Risk In Communities (ARIC); Coronary Artery Risk Development in Young Adults (CARDIA); Cardiovascular Health Study (CHS); Framingham Heart Study (FHS); Multi-Ethnic Study of Atherosclerosis (MESA)
  2. Replication cohorts: BOSS beaver dam offspring study, EHLS epidemiology of hearing loss study, BDES beaver dam eye study, AIBIII Allied Irish Bank Workers Study III, AMC-PAS Academic Medical Center Amsterdam Premature Atherosclerosis Study, ASCOT anglo-scandinavian cardiac outcomes trial, BHS bogalusa heart study, BRIGHT, British genetics of hypertension, BWHHS British women’s heart and health study, CLEAR carotid lesion epidemiology and risk, EPIC-NL European Prospective Investigation into Cancer and Nutrition in the Netherlands, GIRaFH genetic identification of risk factors in familial hypercholesterolemia, KORA Kooperative Gesundheitsforschung in der Region Augsburg, LURIC Ludwigshafen Risk and Cardiovascular Health Study, PROCARDIS precocious coronary artery disease study, WHII Whitehall II study, GWAS eMERGE
  3. aNumbers varied for each lipid trait. The number shown is the maximum number of non-missing individuals for all traits