Table 4 Top 10 captured epistatic interactions associated with AMD. CFH: complement factor H. N/A: no gene is available. MED27: mediator complex subunit 27. KDM4C: lysine (K)-specific demethylase 4C. NCALD: neurocalcin delta. ISCA1: iron-sulfur cluster assembly 1. NEDD9: neural precursor cell expressed developmentally down-regulated 9
From: epiACO - a method for identifying epistasis based on ant Colony optimization algorithm
SNP 1 | SNP 2 | P-value | ||||
|---|---|---|---|---|---|---|
Name | Gene | Chromosome | Name | Gene | Chromosome | |
rs380390 | CFH | 1 | rs1363688 | N/A | 5 | 4.5728 e-09 |
rs380390 | CFH | 1 | rs2224762 | KDM4C | 9 | 3.2929 e-08 |
rs380390 | CFH | 1 | rs1374431 | N/A | 2 | 3.9086 e-08 |
rs1740752 | N/A | 10 | rs1368863 | N/A | 11 | 9.8438 e-08 |
rs380390 | CFH | 1 | rs223607 | N/A | 6 | 1.9797 e-07 |
rs1329428 | CFH | 1 | rs9328536 | MED27 | 9 | 2.1498 e-07 |
rs1740752 | N/A | 10 | rs943008 | NEDD9 | 6 | 3.8365 e-07 |
rs380390 | CFH | 1 | rs718263 | NCALD | 8 | 5.1901 e-07 |
rs380390 | CFH | 1 | rs2402053 | N/A | 7 | 1.1131 e-05 |
rs380390 | CFH | 1 | rs10512174 | ISCA1 | 9 | 3.9083 e-05 |