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Table 1 Summary of related work

From: Feature analysis for classification of trace fluorescent labeled protein crystallization images

Research paper

Image categories

Feature extraction

Classification method

Classification accuracy

Zuk and Ward (1991) [7]

NA

Edge features

Detection of lines using Hough transform and line tracking

Not provided

Walker et al. (2007) [22]

7

Radial and angular descriptors from Fourier Transform

Learning vector quantization

14 - 97% for different categories

Xu et al. (2006) [23]

2

Features from multiscale Laplacian pyramid filters

Neural network

95% accuracy

Wilson (2002) [24]

3

Intensity and geometric features

Naive Bayes

Recall 86% for crystals, 77% for unfavourable objects

Hung et al. (2014) [26]

3

Shape context, Gabor filters and Fourier transforms

Cascade classifier on naive Bayes and random forest

74% accuracy

Spraggon et al. (2002) [17]

6

Geometric and texture features

Self-organizing neural networks

47 to 82% for different categories

Cumba et al. (2003) [8]

2

Radon transform line features and texture features

Linear discriminant analysis

85% accuracy with roc 0.84

Saitoh et al. (2004) [20]

5

Geometric and texture features

Linear discriminant analysis

80 - 98% for different categories

Bern et al. (2004) [15]

5

Gradient and geometric features

Decision tree with hand crafted thresholds

12% FN and 14% FP

Cumba et al. (2005) [9]

2

Texture features, line measures and energy measures

Association rule mining

85% accuracy with ROC 0.87

Zhu et al. (2004) [10]

2

Geometric and texture features

Decision tree with boosting

14.6% FP and 9.6% FN

Berry et al. (2006) [11]

2

NA

Learning vector quantization, self organizing maps and bayesian algorithm

NA

Pan et al. (2006) [12]

2

Intensity stats, texture features, Gabor wavelet decomposition

Support vector machine

2.94% FN and 37.68% FP

Yang et al. (2006) [14]

3

Hough transform, DFT, GLCM features

Hand tuned thresholds

85% accuracy

Saitoh et al. (2006) [16]

5

Texture features, differential image features

Decision tree and SVM

90% for 3-class problem

Po and Laine (2008) [13]

2

Multiscale Laplacian pyramid filters and histogram analysis

Genetic algorithm and neural network

Accuracy: 93.5% with 88% TP and 99% TN

Liu et al. (2008) [21]

Crystal likelihood

Features from Gabor filters, integral histograms, and gradient images

Decision tree with boosting

ROC 0.92

Cumba et al. (2010) [18]

3 and 6

Basic stats, energy, Euler numbers, Radon-Laplacian, Sobel-edge, GLCM

Multiple random forest with bagging and feature subsampling

Recall 80% crystals, 89% precipitate, 98% clear drops

Sigdel et al. (2013) [28]

3

Intensity and blob features

Multilayer perception neural network

1.2% crystal misses with 88% accuracy

Sigdel et al. (2014) [25]

3

Intensity and blob features

Semi-supervised

75% - 85% overall accuracy

Dinc et al. (2014) [27]

3 and 2

Intensity and blob features

5 classifiers, feature reduction using PCA

96% on non-crystals, 95% on likely-leads

Yann et al. (2016) [19]

10

Deep learnining on grayscale image

Deep CNN with 13 layers

90.8% accuracy