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Table 5 Partial correlation analyses for reassessing the relationship of ALDOA and hub genes. Partial correlation analyses were performed in R-package ‘corpcor’ to reassess the relationship between ALDOA and hub genes (the top ranked 10 genes with highest values of either degree or betweenness)

From: Elevated transcriptional levels of aldolase A (ALDOA) associates with cell cycle-related genes in patients with NSCLC and several solid tumors

 

Symbol

HK2

PKM

r p a

P b

r p c

P d

GSE19188

TK1

0.408

6.45E-05

0.424

3.14E-05

CDC45

0.302

3.82E-03

0.356

5.78E-04

CCNB1

0.290

5.51E-03

0.364

4.19E-04

CDC20

0.284

6.77E-03

0.336

1.19E-03

NUP37

0.275

8.74E-03

0.370

3.28E-04

UBE2T

0.264

1.20E-02

0.326

1.73E-03

CDCA8

0.254

1.60E-02

0.278

7.87E-03

CEP55

0.236

2.50E-02

0.310

2.93E-03

CCNB2

0.230

2.90E-02

0.323

1.87E-03

MELK

0.220

3.70E-02

0.299

4.18E-03

PSMB2

0.206

5.20E-02

0.163

1.25E-01

PTTG1

0.193

6.90E-02

0.369

3.40E-04

TCGA-LUAD

TK1

0.442

<2.2E-16

0.296

7.44E-12

PSMB2

0.438

<2.2E-16

0.334

7.99E-15

UBE2T

0.384

<2.2E-16

0.318

1.44E-13

CDC20

0.369

<2.2E-16

0.271

4.34E-10

CCNB1

0.367

<2.2E-16

0.242

2.76E-08

PTTG1

0.347

4.44E-16

0.289

2.39E-11

NUP37

0.346

6.66E-16

0.190

1.44E-05

CCNB2

0.312

4.59E-13

0.150

6.60E-04

CDC45

0.297

6.85E-12

0.184

2.77E-05

CDCA8

0.287

3.08E-11

0.189

1.60E-05

CEP55

0.263

1.40E-09

0.143

1.18E-03

MELK

0.242

2.80E-08

0.157

3.64E-04

  1. a r p was the correlation coefficient between ALDOA and the other genes using partial correlation analyses with P values (b P) when controlling HK2 expression at the transcriptional level; Likewise, c r p was the partial correlation coefficient between ALDOA and the other genes with P values (d P) when controlling PKM expression at the transcriptional level
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ISSN: 1756-0381