Elevated transcriptional levels of aldolase A (ALDOA) associates with cell cycle-related genes in patients with NSCLC and several solid tumors

Table 4 Top ranked 10 genes with highest values of either degree or betweenness. Network analysis in Cytoscape was carried out on GCN. Moderated t-test was performed for examining differential expression of these genes between NSCLC cases and controls (E-GEOD-19188). Pearson’s correlation coefficients were calculated between ALDOA and these genes

Gene ID	Symbol^e	r ^a	P _a value^b	logFC^c	P _a value^d
991	*CDC20*	0.399	0.003	3.234	1.49E-33
9833	*MELK*	0.358	0.008	2.866	3.14E-32
9232	*PTTG1*	0.356	0.009	1.989	7.06E-26
9133	*CCNB2*	0.350	0.010	2.935	3.63E-33
8318	*CDC45*	0.414	0.002	1.933	3.09E-27
79023	NUP37	0.401	0.003	0.894	7.08E-20
891	*CCNB1*	0.395	0.004	2.734	1.14E-32
7083	*TK1*	0.503	<0.001	1.746	4.55E-26
5690	*PSMB2*	0.456	0.001	0.748	1.39E-19
29089	UBE2T	0.363	0.007	2.868	2.27E-38
55143	CDCA8	0.351	0.010	1.817	8.39E-32
55165	CEP55	0.372	0.006	2.754	5.51E-30

^a r was the Pearson’s correlation coefficient of this gene with ALDOA; ^b P _a value was calculated by the Pearson’s correlation method adjusted by Benjamini & Hochberg method.; ^clogFC represented log base 2 of FC, which was the expression level ratio between cancer and control; ^d P _a value was calculated by the Moderated t-statistic method adjusted by Benjamini & Hochberg method. ^eThe bond symbols represented top ranked genes with highest values of degree, while the italic symbols indicated top ranked genes with highest values of betweenness

ISSN: 1756-0381