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Table 3 Correlation of bin size and significance. Using the control weighting, the larger bins result in a higher chance of a false positive finding, showing a correlation between bin size and p-value. All other weighting strategies have false positive rates independent of bin size

From: A biologically informed method for detecting rare variant associations

 

Logistic

Wilcoxon

Beta (SE)

p-value

Beta (SE)

p-value

Control

−6.83e-3 (6.13e-4)

7.51e-29

−5.77e-3 (4.42e-4)

6.07e-39

Max

4.08e-5 (8.40e-5)

0.627

−4.75e-5 (8.39e-5)

0.572

Min

2.88e-5 (8.39e-5)

0.732

5.06e-5 (8.39e-5)

0.546

None

−2.43e-5 (8.38e-5)

0.772

−3.15e-5 (8.38e-5)

0.707

Overall

3.64e-5 (8.38e-5)

0.664

2.05e-5 (8.38e-5)

0.806