Table 2 Type I error results. The Type I error simulation results displayed per BioBin weighting scheme tested, biological bin size assessed, and statistical analysis test
From: A biologically informed method for detecting rare variant associations
Statistical test | Bin size | Weighting scheme | ||||
|---|---|---|---|---|---|---|
Control only weight | Max weight | Min weight | No weight | Overall weight | ||
Logistic | Gene | 0.106 | 0.079 | 0.042 | 0.060 | 0.052 |
XL Gene | 0.343 | 0.096 | 0.042 | 0.062 | 0.057 | |
Pathway | 0.847 | 0.090 | 0.040 | 0.066 | 0.059 | |
Wilcoxon | Gene | 0.064 | 0.061 | 0.052 | 0.060 | 0.057 |
XL Gene | 0.153 | 0.068 | 0.043 | 0.056 | 0.055 | |
Pathway | 0.795 | 0.085 | 0.045 | 0.072 | 0.056 | |