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Table 2 Type I error results. The Type I error simulation results displayed per BioBin weighting scheme tested, biological bin size assessed, and statistical analysis test

From: A biologically informed method for detecting rare variant associations

Statistical test Bin size Weighting scheme
Control only weight Max weight Min weight No weight Overall weight
Logistic Gene 0.106 0.079 0.042 0.060 0.052
XL Gene 0.343 0.096 0.042 0.062 0.057
Pathway 0.847 0.090 0.040 0.066 0.059
Wilcoxon Gene 0.064 0.061 0.052 0.060 0.057
XL Gene 0.153 0.068 0.043 0.056 0.055
Pathway 0.795 0.085 0.045 0.072 0.056