Table 4 Eleven extracted relations with disconnected gene nodes from GeneMANIA
From: Building a glaucoma interaction network using a text mining approach
Gene1 | Gene2 | Confidence | Disconnected node | PMC Excerpt | PMCID/Year | Remark |
|---|---|---|---|---|---|---|
DCDC1 | PAX6 | 0.96 | DCDC1 | ELP4 and DCDC1 are located downstream of PAX6. | PMC2375324/2008 | |
ALB | ELP4 | 0.93 | ELP4 | ALB was used to normalize ELP4 and PAX6 values for the detection of the relative copy number of the deletion region. | PMC3859656/2013 | |
ATOH7 | FBN1 | 0.88 | ATOH7 | We found 10 candidate POAG genes that were highly expressed in both the CPE and NPE (AKAP13, C1QBP, CHSY1, COL8A2, CYP1B1, FBN1, IBTK, MFN2, TMCO1, and TMEM248), three genes that were expressed significantly higher in the CPE (CDH1, CDKN2B, and SIX1), and six genes that were expressed significantly higher in the NPE (ATOH7, CYP1B1, FBN1, MYOC, PAX6, and SIX6). | PMC3909915/2014 | |
FBN1 | TMEM248 | 0.88 | TMEM248 | We found 10 candidate POAG genes that were highly expressed in both the CPE and NPE (AKAP13, C1QBP, CHSY1, COL8A2, CYP1B1, FBN1, IBTK, MFN2, TMCO1, and TMEM248), three genes that were expressed significantly higher in the CPE (CDH1, CDKN2B, and SIX1), and six genes that were expressed significantly higher in the NPE (ATOH7, CYP1B1, FBN1, MYOC, PAX6, and SIX6). | PMC3909915/2014 | |
GSK3B | MTHFR | 0.85 | MTHFR | For example, GSK3B has a direct connection with IL4 and a secondary connection with MTHFR. | PMC2653647/2009 | |
GAPDH | VSX1 | 0.85 | VSX1 | Each bar represents the relative expression of VSX1 normalized to GAPDH in a different tissue/age; mean ± SD (Sc: sclera, Co: cornea, Ir: iris, CB: ciliary body, Len: lens, Cho: | PMC2267740/2008 | |
GLS2 | HMGB1 | 0.80 | GLS2 | the HMGB1 inhibitor GA attenuated diabetes-induced upregulation of HMGB1 and downregulation of BDNF | PMC3671668/2013 | GLS2 is a synonym of GA |
SHH | ATOH7 | 0.78 | ATOH7 | Thus the SHH and GDF11 regulate ATOH7, which in turn regulates Brn3b. | PMC2883590/2010 | |
LMX1B | COL3A1 | 0.45 | LMX1B | Recent immunohistological studies in NPS patients with severe glomerular disease suggest a possible regulation of type III collagen by LMX1B, while the homozygous | PMC2669506/2007 | COL3A1 is a synonym of Type_III_collagen |
NPS | PAX6 | 0.05 | NPS | Research has demonstrated that retinal neurons and RGCs are mainly comprised of anteriorized NPS that express PAX6 and OTX2. | PMC3747054/2013 | |
NPS | OTX2 | 0.05 | NPS | Research has demonstrated that retinal neurons and RGCs are mainly comprised of anteriorized NPS that express PAX6 and OTX2 | PMC3747054/2013 |