Fig. 1
From: Evolutionary triangulation: informing genetic association studies with evolutionary evidence
Limiting the number of SNPs by switching from pairwise to three-way comparison. The number of SNPs identified in pairwise versus three-way population comparisons are illustrated by showing each two-analysis and the three-way overlap. The number in each circle indicates the number of SNPs that are identified under a particular FST threshold for a pairwise comparison; the numbers are shown in the lower left legend. For example, a indicates there are 65119 SNPs under 95th percentile FST threshold in the comparison between CEU and YRI. b shows that there is a significant decrease to 22 SNPs (center triangle) when using a three way comparison under the thresholds of the same stringency