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Fig. 2 | BioData Mining

Fig. 2

From: Network-based analysis of genetic variants associated with hippocampal volume in Alzheimer’s disease: a study of ADNI cohorts

Fig. 2

Network reprioritization of AD GWAS identifies AD-associated genes. GWAS ranked and NetWAS reprioritized genes are assessed for correspondence to genes known to be associated with Alzheimer’s disease. We compared ADNI-1 and ADNI-2 to DO-annotated AD genes using AUC. The AUC for NetWAS in ADNI-1 was significantly higher than that observed for the GWAS or the permuted NetWAS. The AUC for NetWAS in ADNI-2 was significantly higher than the permuted NetWAS. Error bars indicate 95 % confidence intervals via bootstrap

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BioData Mining

ISSN: 1756-0381