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Fig. 1 | BioData Mining

Fig. 1

From: Network-based analysis of genetic variants associated with hippocampal volume in Alzheimer’s disease: a study of ADNI cohorts

Fig. 1

An overview of our analysis. In phase I, we mapped SNPs from the GWAS studies to genes and calculated gene-based p-values from SNP p-values. In phase II, we focused on using hippocampus network to reprioritize these genes. The efficacy of this approach was assessed with documented associations with AD. NetWAS results from different cohorts were integrated using an average-score approach and assessed for concordance with documented AD associations

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BioData Mining

ISSN: 1756-0381