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Fig. 3 | BioData Mining

Fig. 3

From: A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis

Fig. 3

CNV-weighted linkage analysis at 19q13. Linkage scores and CNV-weighted linkage scores are illustrated relative to UCSC genes and structural variations in Data Base of Genomic Variation (DGV). The plotted red linkage curve represents results of the LOD scores from 5 pedigrees (pedigree-id: 29–0209, 29–0174, 26–5011, 20–1049 and 12–330), consisting of 12 individuals (ind-id: 29–10642, 29–10656, 29–10528, 29–10535, 29–10532, 26–50071, 26–50069, 20–10868, 20–10856, 12–11239, 12–11241 and 12–11240) who shared a CNV and which generated CNV-weighted linkage scores (chr19:48066441–48114839 and chr19:48114839–48157656) that survived correction for multiple comparisons (empirical P = 0.033). The green vertical line marks the location of the shared CNV from these 5 families relative to the linkage peak and relative to the UCSC genes. Lower panel displays reported structural variations from DGV. Color scheme of DGV CNVs; blue: gain, red: loss, purple: inversion, black: unknown, and brown: both loss and gain. All genomic coordinates are according to NCBI36/hg18

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