TY - JOUR AU - Lekman, Magnus AU - Karlsson, Robert AU - Graae, Lisette AU - Hössjer, Ola AU - Kockum, Ingrid PY - 2015 DA - 2015/12/18 TI - A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis JO - BioData Mining SP - 42 VL - 8 IS - 1 AB - The genetic background to bipolar disorder (BPD) has been attributed to different genetic and genomic risk factors. In the present study we hypothesized that inherited copy number variations (CNVs) contribute to susceptibility of BPD. We screened 637 BP-pedigrees from the NIMH Genetic Initiative and gave priority to 46 pedigrees. In this subsample we performed parametric and non-parametric genome-wide linkage analyses using ~21,000 SNP-markers. We developed an algorithm to test for linkage restricted to regions with CNVs that are shared within and across families. SN - 1756-0381 UR - https://doi.org/10.1186/s13040-015-0076-y DO - 10.1186/s13040-015-0076-y ID - Lekman2015 ER -