TY - JOUR AU - Liu, Zhenqiu AU - Lin, Shili AU - Piantadosi, Steven PY - 2015 DA - 2015/12/12 TI - Network construction and structure detection with metagenomic count data JO - BioData Mining SP - 40 VL - 8 IS - 1 AB - The human microbiome plays a critical role in human health. Massive amounts of metagenomic data have been generated with advances in next-generation sequencing technologies that characterize microbial communities via direct isolation and sequencing. How to extract, analyze, and transform these vast amounts of data into useful knowledge is a great challenge to bioinformaticians. Microbial biodiversity research has focused primarily on taxa composition and abundance and less on the co-occurrences among different taxa. However, taxa co-occurrences and their relationships to environmental and clinical conditions are important because network structure may help to understand how microbial taxa function together. SN - 1756-0381 UR - https://doi.org/10.1186/s13040-015-0072-2 DO - 10.1186/s13040-015-0072-2 ID - Liu2015 ER -