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Table 2 Combinatorial clusters of chromatin-bound TFs most significantly associated with p65 recruitment

From: Genome-wide predictors of NF-κB recruitment and transcriptional activity

cluster log-odds p-value supp. conf.
creb1-foxa2-jund-rad21 3.20 1.4E-11 7890 0.76
creb1-rad21-usf1-yy1 2.56 1.4E-09 5815 0.67
foxa2-rad21-usf1-yy1 2.03 9.1E-07 5672 0.59
gata3-tcf12-usf1 −4.66 1.1E-08 12907 0.01
creb1-rad21-sp1 2.90 1.4E-26 9415 0.72
max-rad21-sp1 2.74 4.6E-15 10061 0.70
creb1-foxa2-yy1 2.52 1.7E-14 11814 0.67
creb1-max-rad21 2.49 3.6E-87 11088 0.65
creb1-rad21-tcf12 2.49 1.1E-11 8507 0.66
max-rad21-tcf12 2.44 2.6E-09 9096 0.65
creb1-foxa2-sp1 2.35 4.8E-10 18956 0.64
jund-max-rad21 2.24 6.3E-10 9186 0.62
foxa2-max-sp1 2.13 1.8E-06 20425 0.60
gr-max-rad21 2.11 2.8E-12 9346 0.60
jund-pol2-rad21 2.08 7.6E-06 6302 0.60
cebpb-jund-rad21 2.01 6.5E-07 6442 0.58
max-pol2-rad21 2.00 4.5E-17 7741 0.58
cebpb-foxa2-yy1 1.95 2.9E-05 7025 0.58
elf1-foxa2-rad21 1.71 1.9E-08 4304 0.53
foxa2-max-yy1 1.62 4.2E-05 11994 0.52
cebpb-foxa2-usf1 0.90 6.6E-05 12804 0.39
  1. TF-clusters obtained by the TGC algorithm at stage 2 TSS-distal sites. Each cluster is significantly enriched (or depleted) for p65 binding events. The enrichment log-odds and significance are from the Fisher’s exact test. Support (supp.) and confidence (conf.) are calculated genome-wide for all regulatory sites. Support is the number of sites occupied by all TFs from a TF-cluster, confidence is the percentage of these sites that will recruit p65
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