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Table 1 Performance of epigenetic marks in the prediction of p65 binding

From: Genome-wide predictors of NF-κB recruitment and transcriptional activity

  Prox Dist S1 Dist S2 mean ∆mot
h2az 0.72 0.61 0.60 0.64  
h2az + mot 0.80 0.83 0.69 0.77 0.13
h3k27ac 0.70 0.64 0.61 0.65  
h3k27ac + mot 0.80 0.84 0.69 0.78 0.13
h3k27me3 0.52 0.53 0.54 0.53  
h3k27me3 + mot 0.70 0.80 0.66 0.72 0.19
h3k4me1 0.59 0.70 0.59 0.63  
h3k4me1 + mot 0.74 0.86 0.68 0.76 0.14
h3k4me2 0.72 0.70 0.61 0.67  
h3k4me2 + mot 0.80 0.86 0.70 0.79 0.11
h3k4me3 0.70 0.64 0.58 0.64  
h3k4me3 + mot 0.80 0.84 0.68 0.77 0.13
h3k79me2 0.50 0.53 0.53 0.52  
h3k79me2 + mot 0.69 0.80 0.65 0.71 0.20
h3k9ac 0.69 0.64 0.63 0.65  
h3k9ac + mot 0.79 0.84 0.71 0.78 0.13
mot 0.69 0.79 0.63 0.71  
  1. Predictive performance (AUC – area under curve) of single-mark logistic regression models, with optional inclusion of binary NF-κB motif presence (+mot), on the binding of p65 at three classes of sites: Prox – TSS-proximal; Dist S1 – TSS-distal (stage 1); Dist S2 – TSS-distal (stage 2); mean – arithmetic average performance for all classes; ∆mot – arithmetic average improvement of the (+mot) models
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