Skip to main content
Fig. 4 | BioData Mining

Fig. 4

From: Genome-wide predictors of NF-κB recruitment and transcriptional activity

Fig. 4

Cooperativity of transcription factors in p65 recruitment. a Matrix of positive (red) and negative (blue) cooperativity between transcription factors (TFs) in p65 recruitment. Positive (negative) cooperativity means that sites co-occupied by the two TFs have higher (lower) propensity for p65 than sites occupied by any of the TF alone. Only significant enrichments are shown p < 0.05. Enrichments that do not meet a stringent significance level p < 1e-5 are capped at log-odds 2 or −1, respectively. bd Each diagrams represents a single “TF-cluster” obtained using the TGC algorithm (Methods). Each box represents TSS-distal stage 2 sites co-occupied by the indicated transcription factors (TFs). Log-odds enrichment scores are indicated below the TF symbols and are all significant (p < 0.05). Arrows represent the intersection operation. Successive intersections within a single TF-cluster monotonously improve enrichment. b TF-cluster with the highest positive propensity for p65 recruitment c Context dependent role of TCF12. Together with GATA3 and USF1 TCF12 forms the only TF-cluster which is depleted of p65 binding events. Together with CREB1 and RAD21 it forms a TF-cluster with moderate positive cooperativity. d FOXA2 has weak propensity for p65 recruitment on its own, but boosts the propensity of some combinations of TFs

Back to article page
\