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Fig. 1 | BioData Mining

Fig. 1

From: Genome-wide predictors of NF-κB recruitment and transcriptional activity

Fig. 1

General characterization of genome-wide p65 binding. a Recruitment of p65 relative to transcription start sites (TSS) and DNase I hypersensitive (DHS) sites. Numbers in parentheses are totals of sites of a given class. b Likewise, recruitment of p65 relative to DHS and NF-κB motif (MOT) occurrence. c PhastCons placental mammals conservation scores at p65 summits within accessible and inaccessible regulatory sites (see Methods). d Role of CpG methylation in p65 binding. Significant enrichment (red) or depletion (blue) of p65 binding depending on localization (TSS-proximal, TSS-distal), CpG-island (CGI) status (CGI, non-CGI), methylation level (low, medium, high) (see Methods). All shown log-odds are significant (FET p-value < 1e-4)

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