Functional dyadicity and heterophilicity of gene-gene interactions in statistical epistasis networks

Table 1 Dyadicity and heterophilicity analysis results of the bladder cancer gene interaction network

Gene Ontology terms	n ₁	m ₁₁	m ₁₀	\(\overline {m}_{11}\)	\(\overline {m}_{10}\)	D	H	p _D	p _H
Nucleoplasm	30	9	38	4.422	47.265	2.035	0.804	0.042	0.954
Identical protein binding	27	1	56	3.568	43.362	0.280	1.291	0.977	0.026
Response to estrogen stimulus	10	1	29	0.457	17.788	2.186	1.630	0.401	0.015
Transcription, DNA-dependent	9	2	25	0.366	16.101	5.466	1.553	0.062	0.036
RNA biosynthetic process	9	2	25	0.366	16.101	5.466	1.553	0.064	0.036
Steroid binding	8	2	12	0.285	14.393	7.027	0.834	0.042	0.776
Axon	6	2	7	0.152	10.917	13.118	0.641	0.013	0.952
Negative regulation of DNA binding	5	2	11	0.102	9.148	19.676	1.202	0.006	0.301
Regulation of phagocytosis	3	1	7	0.030	5.550	32.794	1.261	0.045	0.260
Nucleotide-excision repair, DNA gap filling	3	0	12	0.030	5.550	0	2.162	1	0.037
Regulation of sterol-transport	3	1	5	0.030	5.550	32.794	0.901	0.047	0.616
Regulation of cholesterol transport	3	1	5	0.030	5.550	32.794	0.901	0.048	0.618

A 100,000-fold permutation testing was used to estimate the significance levels of the calculated D and H, and the p-values less than the threshold 0.05 were noted in bold font

ISSN: 1756-0381