Supervised learning methods in modeling of CD4+ T cell heterogeneity

Table 6 Applying the RF and ANN method on experimental data

Study	Input			Output												Dynamics behavior
	Input			Experimental (EXP)				Model prediction (ANN)				Model prediction (RF)				Up/Down-regulation with respect to control
	IL12	IL6	TGFβ	IL17	RORgt	FOXP3	Tbet	IL17	RORgt	FOXP3	Tbet	IL17	RORgt	FOXP3	Tbet	EXP	ANN / RF
1.[63]		0	0	188				0.14				0.128				↑	↑ / ↑
		100	10	4875				0.99				0.769
2.[63]		0	0		63				0.104				0.103			↑	↑ / ↑
		100	10		485				0.999				0.946
3.[63]		0	0			406				0.0164				0.194		↑	↓ / ↓
		100	10			469				0.0075				0.143
4.[64]		0	0			3.3				0.0164				0.194		↓	↓ / ↓
		20	3			0.6				0.0065				0.143
5.[65]	0						1				0.0602				0.874	↑	↑ / ↑
	10						1.33				0.809				0.992

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