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Table 6 A list of filtered DDI-ADE pairs for the drug “Simvastatin” classified by CTCAE grades

From: Mining severe drug-drug interaction adverse events using Semantic Web technologies: a case study

CTCAE grade AERS outome code Drug code by RxCUI Drug name Drug code by RxCUI Drug name ADE code by MedDRA ADE name
Grede 5 DE 36567 Simvastatin 1191 Aspirin 10002906 Aortic stenosis
Grede 5 DE 253198 Risiglitazone maleate 36567 Simvastatin 10006580 Bundle branch block left
Grede 5 DE 36567 Simvastatin 203160 Losartan Potassium 10007515 Cardiac arrest
Grede 5 DE 36567 Simvastatin 1191 Aspirin 10010071 Coma
Grede 5 DE 253198 Risiglitazone maleate 36567 Simvastatin 10012689 Diabetic retinoathy
Grede 4 LT 36567 Simvastatin 203029 Tegretol 10002948 Aphasia
Grede 4 LT 36567 Simvastatin 203029 Tegretol 10003119 Arrhythmia
Grede 4 LT 253198 Amiodarone hydrochloride 316675 Simvastatin 80 MG 10006002 Bone pain
Grede 4 LT 36567 Simvastatin 225807 exelon 10007515 Cardiac arrest
Grede 4 LT 36567 Simvastatin 203029 Tegretol 10012455 Dematitis exfoliative
Grede 3 DS 36567 Simvastatin 1191 Aspirin 10012455 Dematitis exfoliative
Grede 3 DS 36567 Simvastatin 190465 Viagra 10018429 Glucose tolerance impaired
Grede 3 DS 36567 Simvastatin 83367 Atorvastatin 10020765 Hypersomia
Grede 3 DS 36567 Simvastatin 35296 Ramipril 10050295 Intervertebral disc protrusion
Grede 3 DS 253198 Gemfibrozil 600 MG 316675 Simvastatin 80 MG 10000486 Acidosis