Mining severe drug-drug interaction adverse events using Semantic Web technologies: a case study

Table 6 A list of filtered DDI-ADE pairs for the drug “Simvastatin” classified by CTCAE grades

CTCAE grade	AERS outome code	Drug code by RxCUI	Drug name	Drug code by RxCUI	Drug name	ADE code by MedDRA	ADE name
Grede 5	DE	36567	Simvastatin	1191	Aspirin	10002906	Aortic stenosis
Grede 5	DE	253198	Risiglitazone maleate	36567	Simvastatin	10006580	Bundle branch block left
Grede 5	DE	36567	Simvastatin	203160	Losartan Potassium	10007515	Cardiac arrest
Grede 5	DE	36567	Simvastatin	1191	Aspirin	10010071	Coma
Grede 5	DE	253198	Risiglitazone maleate	36567	Simvastatin	10012689	Diabetic retinoathy
Grede 4	LT	36567	Simvastatin	203029	Tegretol	10002948	Aphasia
Grede 4	LT	36567	Simvastatin	203029	Tegretol	10003119	Arrhythmia
Grede 4	LT	253198	Amiodarone hydrochloride	316675	Simvastatin 80 MG	10006002	Bone pain
Grede 4	LT	36567	Simvastatin	225807	exelon	10007515	Cardiac arrest
Grede 4	LT	36567	Simvastatin	203029	Tegretol	10012455	Dematitis exfoliative
Grede 3	DS	36567	Simvastatin	1191	Aspirin	10012455	Dematitis exfoliative
Grede 3	DS	36567	Simvastatin	190465	Viagra	10018429	Glucose tolerance impaired
Grede 3	DS	36567	Simvastatin	83367	Atorvastatin	10020765	Hypersomia
Grede 3	DS	36567	Simvastatin	35296	Ramipril	10050295	Intervertebral disc protrusion
Grede 3	DS	253198	Gemfibrozil 600 MG	316675	Simvastatin 80 MG	10000486	Acidosis

ISSN: 1756-0381