Alteration of global and modular β -diversity values in distinctive phenotypic states of breast tissue. a Colored matrix representing 105 out of the 240 pair-wise comparisons performed in this study. The colored cells represent tests with FDR corrected P-values < 0.01. Subtype comparisons are ordered based on global β-diversity. Modules are ordered based on the number of subtypes in which they exhibit significantly higher β-diversity than normal breast tissue. Notably purple and blue modules significantly show larger β-diversity in all of the phenotypic states of breast tumor compared to that of normal state. The pink module has been removed from this matrix. The corresponding metastatic states are not shown since none of the subtypes at this state shows significantly different levels of β-diversity when compared to their cancerous counterparts or among themselves (See the text). b Box plots corresponding to the patterns of β-diversity across subtypes. Gray box plots correspond to global β-diversity for the available transcriptome. Colored box plots correspond to modules as indicated in the legend in panel a. Each box plot depicts the distribution of Euclidean distances between patients and their corresponding subtype spatial median (See the text).