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Table 5 Plasma cholesterol-induced lesion networks are enriched for cardiometabolic GxE genes

From: CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits

Network, number of genes*

Genes shared with GxE catalog†

Genes shared with GWAS catalog‡

Enrichment in GxE catalog,p-value

Plasma cholesterol-lowering, 2697

32

80

< 0.001

Regression-reactive, 6096

55

174

< 0.001

  1. *All genes comprising each network, as described [88].
  2. †GxE genes supporting commonly measured phenotypes and involving common environmental modifiers, n =108.
  3. ‡GWAS genes supporting associations with cardiometabolic phenotypes, n =519.
  4. p-value based on two-sample z-test.
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