Table 4 Potential regulatory miRNAs involved in allele-specific miR-mRNA interactions showing GxE interactions
From: CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits
SNP | Lead SNP | Gene | miRSNP confidence score | Potential regulatory miRNAs* | Cardiometabolic GxE, phenotype-environmental factor |
|---|---|---|---|---|---|
rs1063539 | rs1063539 | ADIPOQ | 5 | miR-593-3p | Obesity-PUFA, N-3, DHA + EPA, percent in erythrocyte membranes |
rs12817689 | rs2302706 | MMAB | 7 | miR-33b-3p, miR-371a-3p, miR-371b-3p, miR-515-3p, miR-519e-3p | HDL-C-carbohydrate intake |
rs1491235 | rs1800591 | MTTP-TRMT10A | 5 | miR-33b-5p | APOB-48 in VLDL-high-fat challenge; cholestanol/mol cholesterol, serum, fasting-diet; cholesterol in VLDL-high-fat challenge; ΔLDL-C-SFA, percent energy from; lathosterol/mol cholesterol, serum, fasting-diet; sitosterol/mol cholesterol, serum, fasting-diet |
rs3734254 | rs2076167 | PPARD | 11 | miR-885-3p | ΔHDL-C-physical activity; Δwork output, max-physical activity |
rs4225 | rs5070 | APOC3 | 6 | miR-885-3p | HDL-C-fat, total intake; HDL-C-SFA intake |
rs4707436 | rs1049353 | CNR1 | 12 | miR-593-5p, miR-885-5p | Δcholesterol, total-MUFA, percent energy from; Δcholesterol, total-PUFA, percent energy from; ΔIL6, plasma-physical activity during energy restriction; ΔLDL-C-MUFA, percent energy from; ΔLDL-C-PUFA, percent energy from; Δleptin, plasma-physical activity during energy restriction; Δresistin, plasma-physical activity during energy restriction; ΔTNF, plasma-physical activity during energy restriction |
rs4998 | rs4994 | ADRB3 | 6 | miR-593-5p, miR-885-3p | BMI-energy intake; Δfat mass-physical activity; Δlean mass-physical activity; obesity-physical activity; triglyceride-low-calorie diet |
rs5446 | rs5443 | GNB3 | 10 | miR-33b-3p, miR-371a-3p, miR-371b-3p, miR-515-3p, miR-519e-3p | BMI-physical activity |
rs7021 | rs709592 | PSMD3 | 9 | miR-33b-3p, miR-371a-3p, miR-515-3p, miR-519e-3p | Glucose, fasting-carbohydrate, percent energy from; glucose, fasting-MUFA, percent energy from; insulin resistance (HOMA-IR)-carbohydrate, percent energy from |