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Table 3 Lack of enrichment for liver eQTL in GxE SNPs compared to GWAS SNPs

From: CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits

Dataset

LD blocks: type, n

LD blocks with liver eQTL (%)

p

All cardiometabolic traits

nonGxE GWAS, 549

35 (6.4)

0.26

 

GxE, 178

9 (5.1)

 

HDL-C

nonGxE GWAS, 69

8 (11.6)

0.21

 

GxE, 43

3 (7.0)

 

LDL-C

nonGxE GWAS, 54

6 (11.1)

0.32

 

GxE, 37

3 (8.1)

 

Triglyceride

nonGxE GWAS, 45

7 (15.6)

0.08

 

GxE, 35

2 (5.7)

 

Total cholesterol

nonGxE GWAS, 55

10 (18.2)

0.02

 

GxE, 33

1 (3.0)

 
  1. p-value based on two-sample z-test.