A: Additive dominant | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Marker 1 | Marker 2 | Interaction statistics | ||||||||||||
Cases/Controls with marker 1 and marker 2 conferring risk (1) or no-risk (0) | ||||||||||||||
Permuted | ||||||||||||||
Chr | Gene | Rs | Chr | Gene | Rs | AP (95% C.I.) | AP P | P | PAF | AUC | 00 | 01 | 10 | 11 |
4 | ARHGAP10 | rs9332471 | 4 | ARHGAP10 | rs6845865 | 0.58 (0.39:0.78) | 9.10E-9 | 0.14 | 0.147 | 0.5153 | 1009/1073 | 169/174 | 475/500 | 78/33 |
6 | HTR1E | rs6922679 | 16 | GRIN2A | rs17570500 | *0.71 (0.42:1.002) | 1.92E-6 | 0.57 | 0.142 | 0.5046 | 48/50 | 20/6 | 1332/1388 | 310/321 |
4 | ARHGAP10 | rs9332471 | 4 | ARHGAP10 | rs2306910 | 0.63 (0.37:0.89) | 2.40E-6 | 0.61 | 0.149 | 0.5136 | 1201/1273 | 190/182 | 233/238 | 35/12 |
4 | ARHGAP10 | rs9991394 | 4 | ARHGAP10 | rs12645249 | 0.59 (0.34:0.84) | 2.58E-6 | 0.63 | 0.146 | 0.5173 | 1162/1257 | 332/326 | 154/158 | 47/18 |
9 | GRIN3A | rs7873495 | 11 | GRIK4 | rs10892635 | **-1.08 (-1.56:-0.59) | 1.26E-5 | 0.90 | 0.139 | 0.5216 | 290/258 | 10/30 | 1308/1390 | 122/105 |
12 | GRIN2B | rs12371702 | 9 | GRIN3A | rs13292935 | ***-0.92 (-1.35:-0.50) | 1.89E-5 | 0.95 | 0.146 | 0.5375 | 1003/1122 | 442/377 | 236/202 | 51/82 |
12 | GRIN2B | rs11832404 | 4 | NR3C2 | rs982076 | **-1.23 (-1.81:-0.65) | 3.49E-5 | 0.99 | 0.142 | 0.5266 | 257/182 | 10/24 | 1268/1367 | 92/86 |
12 | GRIN2B | rs11832404 | 11 | GRIK4 | rs7928347 | **-1.27 (-1.89:-0.66) | 5.24E-5 | 0.99 | 0.142 | 0.5300 | 255/185 | 7/18 | 1234/1332 | 87/78 |
4 | ARHGAP10 | rs9332471 | 9 | SLC1A1 | rs184204 | 0.53 (0.27:0.79) | 6.28E-5 | 0.99 | 0.145 | 0.5157 | 1212/1292 | 194/183 | 271/282 | 53/23 |
5 | GRIA1 | rs17114975 | 12 | GRIN2B | rs1012587 | *0.64 (0.33:0.95) | 6.54E-5 | 0.99 | 0.129 | 0.5084 | 83/79 | 24/8 | 1381/1448 | 241/245 |
B: Additive recessive | ||||||||||||||
Marker 1 | Marker 2 | Interaction statistics | ||||||||||||
Cases/Controls with marker 1 and marker 2 conferring risk (1) or no-risk (0) | ||||||||||||||
Permuted | ||||||||||||||
Chr | Gene | Rs | Chr | Gene | Rs | AP (95% C.I.) | AP P | P | PAF | AUC | 00 | 01 | 10 | 11 |
9 | RNF20 | rs16920473 | 12 | GRIN2B | rs2216127 | 0.69 (0.42:0.97) | 7.65E-7 | 0.56 | 0.149 | 0.5238 | 377/446 | 1296/1305 | 12/14 | 46/14 |
4 | ARHGAP10 | rs4835456 | 11 | GRIK4 | rs4936540 | 0.72 (0.42:1.02) | 2.70E-6 | 0.72 | 0.148 | 0.5136 | 1105/1176 | 22/23 | 582/571 | 22/6 |
4 | ARHGAP10 | rs6824449 | 16 | SLC6A2 | rs192303 | ***-1.28 (-1.85:-0.72) | 8.30E-6 | 0.86 | 0.149 | 0.5319 | 1293/1414 | 208/159 | 184/144 | 16/32 |
16 | GRIN2A | rs4782040 | 11 | GRIK4 | rs11218032 | ***-0.99 (-1.43:-0.55) | 8.73E-6 | 0.87 | 0.149 | 0.5211 | 1244/1306 | 122/126 | 250/207 | 9/32 |
12 | GRIN2B | rs3764030 | 5 | HTR4 | rs6865654 | 0.68 (0.37:0.99) | 1.27E-5 | 0.91 | 0.148 | 0.5063 | 1363/1423 | 47/48 | 231/235 | 22/7 |
11 | GRIK4 | rs7939968 | 4 | NR3C2 | rs12641471 | 0.52 (0.28:0.76) | 2.03E-5 | 0.94 | 0.144 | 0.5170 | 1088/1165 | 192/186 | 275/292 | 69/32 |
4 | ARHGAP10 | rs6824449 | 16 | GRIN2A | rs11640235 | ***-1.01 (-1.56:-0.55) | 3.60E-5 | 0.98 | 0.149 | 0.5204 | 1355/1435 | 210/163 | 105/108 | 8/25 |
11 | GRIK4 | rs7939968 | 4 | NR3C2 | rs4835508 | 0.51 (0.27:0.75) | 3.77E-5 | 0.98 | 0.143 | 0.5186 | 1029/1118 | 185/179 | 275/295 | 70/33 |
11 | GRIK4 | rs7939968 | 4 | ARHGAP10 | rs12641157 | 0.64 (0.33:0.94) | 5.05E-5 | 0.99 | 0.148 | 0.5178 | 1347/1444 | 260/229 | 93/95 | 26/8 |
3 | HTR3C | rs6766410 | 6 | LAMA4 | rs6913656 | ***-0.84 (-1.25:-0.43) | 5.48E-5 | 0.99 | 0.148 | 0.5216 | 1210/1279 | 243/207 | 217/218 | 21/49 |
C: Multiplicative dominant | ||||||||||||||
Marker 1 | Marker 2 | Interaction statistics | ||||||||||||
Cases/Controls with marker 1 and marker 2 conferring risk (1) or no-risk (0) | ||||||||||||||
Permuted | ||||||||||||||
Chr | Gene | Rs | Chr | Gene | Rs | OR (95% C.I.) | P | P | PAF | AUC | 00 | 01 | 10 | 11 |
4 | GRIA2 | rs17244157 | 16 | GRIN2A | rs1861192 | 0.44 (0.30:0.64) | 2.39E-5 | 0.85 | 0.120 | 0.5442 | 712/838 | 175/120 | 589/539 | 98/120 |
9 | SLC1A1 | rs10974611 | 6 | LAMA4 | rs2032568 | 0.47 (0.38:0.67) | 3.60E-5 | 0.92 | 0.125 | 0.5389 | 536/624 | 154/116 | 699/682 | 145/195 |
12 | GRIN2B | rs12371702 | 9 | GRIN3A | rs13292935 | 0.41 (0.26:0.62) | 3.72E-5 | 0.95 | 0.114 | 0.5375 | 1003/1122 | 442/377 | 236/202 | 51/82 |
4 | GRIA2 | rs17244157 | 16 | GRIN2A | rs16966731 | 0.45 (0.31:0.66) | 3.78E-5 | 0.95 | 0.127 | 0.5322 | 572/642 | 147/88 | 798/808 | 135/162 |
21 | GRIK1 | rs379182 | 11 | GRIK4 | rs17124632 | 0.24 (0.12:0.48) | 4.41E-5 | 0.97 | 0.148 | 0.5244 | 80/111 | 46/14 | 1165/1221 | 357/342 |
10 | RPP30 | rs11186343 | 7 | HTR5A | rs2919435 | 2.49 (1.60:3.89) | 5.51E-5 | 0.98 | 0.130 | 0.5295 | 145/97 | 58/89 | 951/1028 | 558/555 |
3 | NR1I2 | rs6438549 | 12 | GRIN2B | rs12823982 | 0.45 (0.30:0.67) | 7.17E-5 | 0.99 | 0.114 | 0.5333 | 927/1011 | 222/182 | 505/473 | 67/105 |
13 | HTR2A | rs666693 | 22 | COMT | rs8185002 | 3.05 (1.75:5.31) | 8.82E-5 | 0.99 | 0.148 | 0.5325 | 596/548 | 34/61 | 927/1011 | 83/58 |
4 | NR3C2 | rs7691663 | 5 | GRIA1 | rs1422897 | 2.09 (1.44:3.02) | 1.02E-4 | 0.99 | 0.110 | 0.5310 | 124/85 | 445/490 | 185/237 | 977/964 |
19 | GRIK5 | rs4803523 | 5 | GRIA1 | rs13359392 | 2.31 (1.51:3.55) | 1.27E-4 | 1.0 | 0.144 | 0.5350 | 548/487 | 58/90 | 962/1068 | 161/135 |
D: Multiplicative recessive | ||||||||||||||
Marker 1 | Marker 2 | Interaction statistics | ||||||||||||
Cases/Controls with marker 1 and marker 2 conferring risk (1) or no-risk (0) | ||||||||||||||
Permuted | ||||||||||||||
Chr | Gene | Rs | Chr | Gene | Rs | OR (95% C.I.) | P | P | PAF | AUC | 00 | 01 | 10 | 11 |
5 | GRIA1 | rs574071 | 11 | HTR3B | rs1672717 | 0.52 (0.39:0.71) | 2.72E-5 | 0.70 | 0.132 | 0.5433 | 371/473 | 701/646 | 222/182 | 305/346 |
4 | NR3C2 | rs7691663 | 5 | GRIA1 | rs9686702 | 1.84 (1.38:2.44) | 3.28E-5 | 0.76 | 0.117 | 0.5375 | 270/211 | 313/374 | 445/516 | 703/679 |
3 | GSK3B | rs1719889 | 16 | GRIN2A | rs1102967 | 0.55 (0.41:0.73) | 3.30E-5 | 0.76 | 0.139 | 0.5423 | 228/345 | 569/517 | 308/289 | 534/552 |
11 | GRIA4 | rs17104807 | 22 | COMT | rs2020917 | 2.39 (1.57:3.63) | 4.56E-5 | 0.86 | 0.118 | 0.5386 | 98/86 | 643/719 | 86/149 | 848/784 |
12 | GRIN2B | rs3764030 | 16 | GRIN2A | rs1868289 | 4.99 (2.26:11.03) | 6.95E-5 | 0.96 | 0.133 | 0.5169 | 41/13 | 29/44 | 695/742 | 948/970 |
5 | GRIA1 | rs574071 | 16 | GRIN2A | rs1070548 | 2.21 (1.48:3.31) | 1.17E-4 | 0.99 | 0.142 | 0.5284 | 517/532 | 819/860 | 70/110 | 186/135 |
9 | NTRK2 | rs1624327 | 16 | GRIN2A | rs1097784 | 1.94 (1.38:2.72) | 1.19E-4 | 0.99 | 0.138 | 0.5332 | 562/581 | 639/662 | 128/186 | 237/178 |
4 | ARHGAP10 | rs6824449 | 16 | SLC6A2 | rs192303 | 0.27 (0.14:0.54) | 1.68E-4 | 1.0 | 0.119 | 0.5319 | 1293/1414 | 208/159 | 184/144 | 16/32 |
6 | GRIK2 | rs7770500 | 6 | LAMA4 | rs2072019 | 2.06 (1.41:3.00) | 1.76E-4 | 1.0 | 0.116 | 0.5133 | 139/102 | 666/719 | 119/164 | 792/781 |
9 | SLC1A1 | rs7022369 | 5 | GRIA1 | rs12658202 | 1.92 (1.36:2.71) | 1.98E-4 | 1.0 | 0.067 | 0.5285 | 100/147 | 281/326 | 399/352 | 957/952 |
E: MDR | ||||||||||||||
Marker 1 | Marker 2 | Interaction statistics | ||||||||||||
Cases/Controls with genotype combination at predicted risk group | ||||||||||||||
Chr | Gene | Rs | Chr | Gene | Rs | Balanced accuracy | PAF | OR (95% C.I.) | P | High risk | Low risk | TPR | FPR | |
12 | GRIN2B | rs1012587 | 3 | HTR3C | rs6762938 | 0.5513 | 0.0980 | 1.51 (1.32:1.73) | 1.168E-09 | 907/751 | 825/1032 | 0.524 | 0.421 | |
16 | GRIN2A | rs8045893 | 3 | HTR3C | rs6762938 | 0.5498 | 0.0900 | 1.49 (1.30:1.71) | 4.452E-09 | 1033/887 | 699/896 | 0.596 | 0.497 | |
6 | HTR1E | rs17222848 | 5 | GRIA1 | rs17515709 | 0.5480 | 0.0950 | 1.47 (1.28:1.68) | 1.707E-08 | 933/790 | 799/993 | 0.539 | 0.443 | |
11 | GRIA4 | rs609665 | 6 | GRIK2 | rs2518171 | 0.5476 | 0.0917 | 1.46 (1.28:1.68) | 2.051E-08 | 982/842 | 750/941 | 0.567 | 0.472 | |
6 | GRIK2 | rs17828670 | 3 | GSK3B | rs6771023 | 0.5470 | 0.0894 | 1.46 (1.28:1.67) | 2.757E-08 | 1021/884 | 711/899 | 0.589 | 0.554 | |
13 | HTR2A | rs9526240 | 11 | BDNF | rs6265 | 0.5468 | 0.0912 | 1.45 (1.27:1.66) | 3.643E-08 | 984/847 | 748/936 | 0.568 | 0.475 | |
16 | SLC6A2 | rs1814270 | 6 | FKBP5 | rs9462104 | 0.5465 | 0.1020 | 1.46 (1.28:1.68) | 3.031E-08 | 809/668 | 923/1115 | 0.467 | 0.375 | |
13 | HTR2A | rs17288723 | 9 | GRIN3A | rs11788456 | 0.5454 | 0.0937 | 1.44 (1.26:1.64) | 8.039E-08 | 936/802 | 796/981 | 0.540 | 0.500 | |
12 | GRIN2B | rs10845847 | 12 | GRIN2B | rs12301788 | 0.5454 | 0.0809 | 1.48 (1.29:1.71) | 2.458E-08 | 1180/1053 | 552/730 | 0.681 | 0.591 | |
17 | SLC6A4 | rs2020939 | 6 | GRIK2 | rs2749074 | 0.5448 | 0.1012 | 1.44 (1.26:1.65) | 8.982E-08 | 812/677 | 920/1106 | 0.469 | 0.380 |