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Table 2 Results of implementing the DiCE evidence scoring system in four contexts

From: Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors

Gene and phenotype

Omic/Observational evidence

Biological database evidence

Experimental evidence

Total evidence score*

 

Single finding

Validation

   

Hemoglobin S and malaria resistance (a positive control that would not be detected with traditional methods)

1

2

3

3

9

ATP2B4 and malaria resistance (new lead)

1

2

3

3

9

MARVELD3 and malaria resistance (new lead)

1

0

0

0

1

PPARγ and type 2 diabetes (another positive control that would not be detected with traditional methods)

0

0

3

3

6

  1. *a total score of 6–10 is considered strong evidence.