Table 1 Diverse Convergent Evidence (DiCE) point system concept
Omic/Observational evidence | Biological database (Informatic) evidence | Experimental (Laboratory) evidence |
|---|---|---|
Single Significant Finding | Evidence from PubMed, KEGG, GEO, GO or etc. linking the factor to the pathophysiology | Evidence from animal or cell/molecular models demonstrating a role of the factor in the pathophysiology |
Yes (1 point) | Yes (3 points) | Yes (3 points) |
No (0 points) | No (0 points) | No (0 points) |
And Either | Â | Â |
Standard Statistical Validation (3 points) or | Â | Â |
Alternative Statistical Validation (2 points) or | Â | Â |
No Statistical Validation (0 points) | Â | Â |