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Table 2 False positive percentages of MB-MDR involving pairs other than the interacting pair (SNP1, SNP2)

From: A robustness study of parametric and non-parametric tests in model-based multifactor dimensionality reduction for epistasis detection

  Trait status False positives
g 2 Distributions Variances ST WT Rank_ST Rank_WT Log_ST Log_WT Rtn_ST Rtn_WT
  Normal Equal 0.040 0.047 0.053 0.048 0.051 0.047 0.050 0.051
  Normal Unequal 0.051 0.060 0.044 0.061 0.052 0.065 0.048 0.068
  Chi-square Equal 0.037 0.056 0.051 0.053 0.042 0.054 0.045 0.056
0.05 Chi-square Unequal 0.040 0.055 0.047 0.042 0.042 0.053 0.047 0.052
  t-distribution Equal 0.051 0.048 0.048 0.051 0.047 0.047 0.047 0.033
  t-distribution Unequal 0.053 0.047 0.058 0.057 0.054 0.048 0.051 0.052
  Normal Equal 0.040 0.067 0.058 0.058 0.053 0.061 0.054 0.063
  Normal Unequal 0.050 0.065 0.044 0.058 0.048 0.063 0.045 0.057
  Chi-square Equal 0.048 0.059 0.061 0.060 0.053 0.055 0.057 0.056
0.1 Chi-square Unequal 0.063 0.041 0.051 0.041 0.061 0.040 0.053 0.036
  t-distribution Equal 0.048 0.053 0.047 0.049 0.050 0.054 0.044 0.051
  t-distribution Unequal 0.033 0.050 0.055 0.059 0.036 0.051 0.037 0.051
  1. Legend False positive percentage is defined as the proportion of simulation samples for which at least one pair other than the causal pair (SNP1, SNP2) are significant.
  2. ST=Student’s t-test, WT=Welch’s t-test, Rank_ST (Rank_WT)=Student’s t-test (Welch’s t-test) on trait ranks, Log_ST (Log_WT)=Student’s t-test (Welch’s t-test) on log transformed trait, Rtn_ST (Rtn_WT)= Student’s t-test (Welch’s t-test) on trait rank transformed to normal.