Table 2 False positive percentages of MB-MDR involving pairs other than the interacting pair (SNP1, SNP2)

From: A robustness study of parametric and non-parametric tests in model-based multifactor dimensionality reduction for epistasis detection

	Trait status		False positives
g ²	Distributions	Variances	ST	WT	Rank_ST	Rank_WT	Log_ST	Log_WT	Rtn_ST	Rtn_WT
	Normal	Equal	0.040	0.047	0.053	0.048	0.051	0.047	0.050	0.051
	Normal	Unequal	0.051	0.060	0.044	0.061	0.052	0.065	0.048	0.068
	Chi-square	Equal	0.037	0.056	0.051	0.053	0.042	0.054	0.045	0.056
0.05	Chi-square	Unequal	0.040	0.055	0.047	0.042	0.042	0.053	0.047	0.052
	t-distribution	Equal	0.051	0.048	0.048	0.051	0.047	0.047	0.047	0.033
	t-distribution	Unequal	0.053	0.047	0.058	0.057	0.054	0.048	0.051	0.052
	Normal	Equal	0.040	0.067	0.058	0.058	0.053	0.061	0.054	0.063
	Normal	Unequal	0.050	0.065	0.044	0.058	0.048	0.063	0.045	0.057
	Chi-square	Equal	0.048	0.059	0.061	0.060	0.053	0.055	0.057	0.056
0.1	Chi-square	Unequal	0.063	0.041	0.051	0.041	0.061	0.040	0.053	0.036
	t-distribution	Equal	0.048	0.053	0.047	0.049	0.050	0.054	0.044	0.051
	t-distribution	Unequal	0.033	0.050	0.055	0.059	0.036	0.051	0.037	0.051

Legend False positive percentage is defined as the proportion of simulation samples for which at least one pair other than the causal pair (SNP1, SNP2) are significant.
ST=Student’s t-test, WT=Welch’s t-test, Rank_ST (Rank_WT)=Student’s t-test (Welch’s t-test) on trait ranks, Log_ST (Log_WT)=Student’s t-test (Welch’s t-test) on log transformed trait, Rtn_ST (Rtn_WT)= Student’s t-test (Welch’s t-test) on trait rank transformed to normal.

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ISSN: 1756-0381

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