Figure 9

Modeling Example using Biofilter. This is an example of mapping the input list of SNPs to genes within Biofilter; using all of the SNPs on the first “chromosome” (the grey bar at the bottom of (A)). Note that Gene F does not contain any SNPs. Biofilter will then connect, pairwise, the genes that contain pairs of SNPs from the input list of SNPs. Genes A and C are found together in three groups across two sources (B). The other genes on the first chromosome were not found as a pair in any of the other groups. Both the light and paint sources contain groups—blue, gray, and cyan—that suggest a relationship between genes A and C. This relationship will be summarized by the implication score “2-3,” which gives the number of sources followed by the number of groups which support this gene model. Each time the same pairwise model of genes is found in another source, the left-hand index of the implication score for that pairwise model increases by one; each time it is found in another group from the same source, the right-hand index increases by one. Biofilter will next break down the gene-gene models into all pairwise combinations of SNPs across the genes within sources light and paint (C), resulting in pairwise combinations of the SNPs rs11, rs12, rs15, and rs16.