Table 2 AACDS classification of homozygous nsSNPs in 12 genomes
| Â | Features of SNP | Subject id, ethnicity, sex | Total #nsSNPs | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Disease-causing | Deleterious count ≥ 3 | In disease genes | In trait genes | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | |||
Afr, F | Afr, F | Afr, F | Afr, F | Cau, F | Cau, F | Cau, F | Cau, F | Cau, M | Cau, M | Cau, M | Cau, M | |||||||
Category | 1 | X | Â | Â | Â | 1 | None | None | None | 1 | None | None | 1 | 1 | None | 1 | None | 5 |
2A | Â | Â | X | Â | 8 | 7 | 6 | 5 | 6 | 5 | 11 | 7 | 12 | 7 | 10 | 9 | 93 | |
2B | Â | X | X | Â | 1 | None | None | None | 2 | 2 | 4 | 1 | 2 | None | 2 | None | 14 | |
3A | Â | Â | Â | X | 9 | 24 | 17 | 7 | 6 | 10 | 9 | 10 | 5 | 13 | 16 | 10 | 136 | |
3B | Â | X | Â | X | 1 | 5 | None | none | 1 | 1 | 3 | 4 | 2 | 2 | None | 2 | 21 | |
4 | Â | X | Â | Â | 5 | 5 | 8 | 6 | None | 5 | 3 | 7 | 4 | 6 | 5 | 4 | 58 | |
5 | Â | Â | X | X | 14 | 21 | 20 | 10 | 8 | 12 | 9 | 11 | 13 | 18 | 20 | 14 | 170 | |
6 | Â | Â | Â | Â | 68 | 40 | 49 | 42 | 46 | 32 | 33 | 33 | 40 | 56 | 45 | 55 | 539 | |
Total #unique nsSNPs | 88 | 71 | 77 | 58 | 57 | 52 | 50 | 55 | 60 | 82 | 72 | 75 | 797 | |||||